Evaluating shock index as a prognostic tool in septic shock patients

Authors

  • Srikesh Laguvaram Department of Paediatrics, Navodaya Medical College Hospital and Research Centre, Karnataka, India https://orcid.org/0009-0006-1411-289X
  • Pranam G. M. Department of Paediatrics, Navodaya Medical College Hospital and Research Centre, Karnataka, India
  • Usha Hirevenkanagoudar Department of Paediatrics, Navodaya Medical College Hospital and Research Centre, Karnataka, India
  • Sanjeev Chetty Department of Paediatrics, Navodaya Medical College Hospital and Research Centre, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20250084

Keywords:

Septic shock, Paediatric intensive care units, Triage, Systolic blood pressure

Abstract

Background: Septic shock is a leading cause of morbidity and mortality in children worldwide. The shock index (SI), defined as a quotient obtained by dividing the heart rate (HR) with systolic blood pressure (SBP), is a potential tool that may aid in early prognostication of outcomes in paediatric septic shock, though data on its utility remains limited.

Methods: A hospital-based cross-sectional study was conducted in the paediatric intensive care unit (PICU) at Navodaya Medical College, Raichur, over one year. A total of 100 children aged 1 month to 12 years with septic shock were included. SI values were calculated and analysed for their association with inotrope requirement, multiple organ dysfunction syndrome (MODS), length of PICU stay, and outcomes. Children with cardiogenic, hypovolemic, or obstructive shock and those previously treated at other centres were excluded.

Results: Out of 100 children with septic shock, 76 survived and 24 died, with a mortality rate of 24%. Elevated SI values (>1.2) were seen in 78%, correlating with disease severity. Survivors had a mean SI of 0.9±0.1, while non-survivors had 1.3±0.2 (p<0.05). Among elevated SI cases, 64% required inotropes, and 42% developed MODS compared to 8% with normal SI (p<0.01). The average PICU stay was longer for elevated SI cases (7±3 days versus 4±1 days). Persistently high SI values predicted poor outcomes and mortality.

Conclusions: Elevated SI can be a valuable non-invasive parameter that aids health care professionals in triaging sick children in a limited resource setting, allowing for timely referral to higher centres. Continuous monitoring of SI trends alongside HR and SBP can aid in early identification of high-risk patients, enabling timely and targeted interventions.

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References

Kurade A, Dhanawade S. Clinical profile and outcome of septic shock in children admitted to a tertiary care referral hospital. Int J Pediatr Res. 2016;3(4):225-30. DOI: https://doi.org/10.17511/ijpr.2016.i04.04

Rousseaux J, Pons O, Dupont S, Martin S, Petit L, Bernard C. Prognostic value of shock index in children with septic shock. Pediatr Emerg Care. 2013;29(10):1055-9. DOI: https://doi.org/10.1097/PEC.0b013e3182a5c99c

Koch E, Stone M, Day G, Roberts J, McGrath J, Larkin J. Shock index in the emergency department: utility and limitations. Open Access Emerg Med. 2019;11:179-99. DOI: https://doi.org/10.2147/OAEM.S178358

Vandewalle R, Stone C, Jensen A, Baker J, Greenberg M, Holloway T, et al. Trends in pediatric-adjusted shock index predict morbidity in children with moderate blunt injuries. Pediatr Surg Int. 2019;35:785-91. DOI: https://doi.org/10.1007/s00383-019-04469-2

Prasad KJD, Bindu KCH, Abhinov T, Moorthy K, Rajesh K. A comparative study on predictive validity of modified shock index, shock index, and age shock index in predicting the need for mechanical ventilation among sepsis patients in a tertiary care hospital. J Emerg Trauma Shock. 2023;16(1):17-21. DOI: https://doi.org/10.4103/jets.jets_118_22

Yasaka Y, Khemani RG, Markovitz BP, Patel T, Williams H, Gomez A. Is shock index associated with outcome in children with sepsis/septic shock? Pediatr Crit Care Med. 2013;14(8):e372-9. DOI: https://doi.org/10.1097/PCC.0b013e3182975eee

Sankaran P, Kamath AV, Tariq SM, Patel S, Green R, Harrison L, et al. Are shock index and adjusted shock index useful in predicting mortality and length of stay in community-acquired pneumonia? Eur J Intern Med. 2011;22:282-5. DOI: https://doi.org/10.1016/j.ejim.2010.12.009

Larsen GY, Mecham N, Greenberg R, Martinez L, Hughes B, Lopez T, et al. An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics. 2011;127:e1585-92. DOI: https://doi.org/10.1542/peds.2010-3513

Kutko MC, Calarco MP, Flaherty MB, Helmrich RF, Ushay HM, Pon S, et al. Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med. 2003;4(3):333-7. DOI: https://doi.org/10.1097/01.PCC.0000074266.10576.9B

Huang KC, Yang Y, Li CJ, Cheng FJ, Huang YH, Chuang PC, et al. Shock Index, Pediatric Age-Adjusted Predicts Morbidity and Mortality in Children Admitted to the Intensive Care Unit. Front Pediatr. 2021;9:727466. DOI: https://doi.org/10.3389/fped.2021.788361

Maheshwari K, Nathanson BH, Munson SH, Hwang S, Yapici HO, Stevens M, et al. Abnormal shock index exposure and clinical outcomes among critically ill patients: A retrospective cohort analysis. J Crit Care. 2020;57:5-12. DOI: https://doi.org/10.1016/j.jcrc.2020.01.024

Bagali RA, Vinod S, Oommen RA, Shetty AU, Soans ST. Prognostic value of shock index in children with septic shock. Int J Adv Res. 2023;11:1092-6. DOI: https://doi.org/10.21474/IJAR01/16539

Khan KA, Zainulabedeen M. Prognostic value of shock index in children with sepsis/septic shock. Int J Med Res. 2023;14(2):975-83.

López-Reyes CS, Baca-Velázquez LN, Villasis-Keever MA, Zurita-Cruz JN. Shock index utility to predict mortality in pediatric patients with septic shock or severe sepsis. Boletin Medico del Hospital Infantil de Mexico. 2018;75:192-8. DOI: https://doi.org/10.24875/BMHIM.M18000027

Radhakrishnan M, Nagaraja SB. Modified Kuppuswamy socioeconomic scale 2023: stratification and updates. Int J Community Med Public Health. 2023;10:4415-8. DOI: https://doi.org/10.18203/2394-6040.ijcmph20233487

Ray S, Cvetkovic M, Brierley J, Lutman DL, Pathan N, Ramnarayan P, et al. Shock index values and trends in pediatric sepsis. Shock. 2016;46(3):279-86. DOI: https://doi.org/10.1097/SHK.0000000000000634

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Published

2025-01-27

How to Cite

Laguvaram, S., G. M., P., Hirevenkanagoudar, U., & Chetty, S. (2025). Evaluating shock index as a prognostic tool in septic shock patients. International Journal of Contemporary Pediatrics, 12(2), 200–203. https://doi.org/10.18203/2349-3291.ijcp20250084

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Original Research Articles