A study on clinical profile and correlation between electroencephalogram and neuroimaging in unprovoked seizures in children aged between 2 months to 12 years
DOI:
https://doi.org/10.18203/2349-3291.ijcp20250094Keywords:
Seizures, Electroencephalogram, Computed tomography and magnetic resonance imagingAbstract
Background: Seizure is one of the commonest neurological illnesses in children and is also an important cause of mortality and morbidity in childhood proper diagnosis and management helps in improving the everyday life of children with seizures. The study is conducted to find the clinical profile and correlation of electroencephalogram (EEG) and neuroimaging and their correlation in the unprovoked afebrile seizures in children aged between 2 months and 12 years.
Methods: This is a hospital based prospective observational study conducted for a period of 1 year and total of 63 children were included in the study with unprovoked seizures admitted in pediatric department of government Cuddalore medical college and hospital, Chidambaram. The data regarding their name, age, sex, type of seizure, past history of seizures, treatment history, developmental history, family history and EEG/neuroimaging findings are collected and recorded in a preformed proforma and analysed.
Results: Among the 63 children, majority belonged to 1-5 years age group with male preponderance. About 80% of patient had generalised seizures and 20% had focal seizures. About 90% had abnormal EEG whereas 25.8% had abnormal neuroimaging. Majority of the abnormal neuroimaging is shared by focal seizures group. About 83% of children required single antiepileptic only.
Conclusions: The EEG abnormality occurred equally in both generalised and focal seizures. Higher incidence of neuroimaging abnormality is seen in focal seizures. Idiopathic seizures were the most common etiology. There is a higher correlation between neuroimaging abnormality and EEG changes in focal seizures than generalised seizures. Electroencephalogram and neuroimaging are mandatory in evaluating children with unprovoked seizures.
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References
Fisher RS, Cross JH, D’Souza L, French JA. On behalf of ILAE commission for classification and terminology-instruction manual for the ILAE 2017 operational classification of seizure types-Epilepsia. 2017;58(4):531-42. DOI: https://doi.org/10.1111/epi.13671
Vykuntaraju K, Preeti K, Naveen B, Asha B. Etiological Profile of Afebrile Seizures in infants in a tertiary care centre from Southern India. J Paediatr Neurosci. 2019;4(2):82-5. DOI: https://doi.org/10.4103/jpn.JPN_61_18
Muniswamappa JK, Rudrappa S, Patagar PM. Clinico-etiological profile of first episode of seizure and its correlation with electroencephalogram in children aged 2 months to 18 years. Int J Contemp Pediatr 2021;8:1833-6. DOI: https://doi.org/10.18203/2349-3291.ijcp20214155
Nelson textbook of paediatrics 22nd edition. Behrman, Kliegman, Jenson, Elsevier publication. 2033;2013-33.
Kaushik JS, Rajni F. Electroencephalography in Pediatric Epilepsy. Indian Paediatr. 2018;55(10):893-901. DOI: https://doi.org/10.1007/s13312-018-1403-4
Redda TH, Lars F, Jan E. Incidence of Epilepsy in Rural Central Ethiopia. Epilepsia. 1997;38(5)541-6. DOI: https://doi.org/10.1111/j.1528-1157.1997.tb01138.x
Zajac A, Kubik A, Kaci A, Ski M. Assessment of EEG in children with partial epilepsy. Przegl Lek. 2006;63(11):1181-90.
Baheti R, Gupta BR, Baheti R. A study of CT and EEG findings in patients with generalized or partial seizures in Western Rajasthan. J Indian Acad Clin Med. 2003;4:25-9.
Pravalika M, Monika R, Balagopal M. A Study of childhood Seizures and incidence of findings in EEG and Neuroimaging in a tertiary care hospital in a suburban population. J Pharmaceutical Negative Results. 2022;13(1):2233-6.
Misra S, Das BK, Srivastava AK. Neuroimaging Study in Children with Seizures. JNPS. 2007;2(7):13-6.
Rasool A, Choh SA, Wani NA, Ahmad SM, Iqbal Q. Role of electroencephalogram and neuroimaging in first onset afebrile and complex febrile seizures in children from Kashmir. J Pediatr Neurosci. 2012;7(1):9-15. DOI: https://doi.org/10.4103/1817-1745.97611
Hirtz D, Ashwal S, Berg A, Bettis D, Canfield C, Camfield P, et al. Practice parameter: Evaluating a first nonfebrile seizure in children: Report of the quality standards subcommittee of the American Academy of Neurology, the Child Neurology Society and the American Epilepsy Society. Neurology. 2000;55(5):616-23. DOI: https://doi.org/10.1212/WNL.55.5.616
Obajimi M, Fatunde OJ, Ogunseyinde AO, Omigbodun OO, Atalabi OM, Joel RU. Computed tomography and childhood seizure disorder in Ibadan. West Afr J Med. 2004;23(2):167-72. DOI: https://doi.org/10.4314/wajm.v23i2.28112
Berg AT, Testa FM, Levy SR, Shinnar S. Neuroimaging in Children with Newly Diagnosed Epilepsy: A Community-Based Study Pediatrics. 2000;106(3):527-32. DOI: https://doi.org/10.1542/peds.106.3.527
Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Eng J Med. 2000;342(5):314-9. DOI: https://doi.org/10.1056/NEJM200002033420503