Thyroid function test in nephrotic syndrome children who are admitted in emergency ward of Government Tirunelveli Medical College and Hospital, India


  • J. Rukmani Department of Pediatrics, Government Tirunveli Medical College, Tirunelveli, Tamil Nadu, India
  • C. Krishanamurthy Department of Pediatrics, Government Tirunveli Medical College, Tirunelveli, Tamil Nadu, India
  • Denny Clarin Department of Pediatrics, Government Tirunveli Medical College, Tirunelveli, Tamil Nadu, India



Nephrotic syndrome, Steroid-Resistant Nephrotic Syndrome (SRNS), Steroid-Dependent Nephrotic Syndrome (SDNS), Thyroid function test.


Background: Nephrotic syndrome in childhood is largely primary or idiopathic, although a small proportion of cases are secondary to infectious agents and other glomerular and systemic diseases. The etiology of nephrotic syndrome is age-dependent. Most cases appearing in the first 3 months of life are referred as congenital nephrotic syndrome (CNS) and are due to genetic diseases. The objective of this study is to study the correlation between thyroid profile and different types of nephrotic syndrome.

Methods: This cross-sectional study was done between March 2017 to October 2017 in the Department of Pediatrics Tirunelveli Government Medical College. 40 cases of nephrotic syndrome between 1 to12 years, which include all types of nephrotic syndrome. After history taking and clinical examination, blood samples were collected from the patients for thyroid function test and analyzed with standard techniques.

Results: Serum T3, T4, TSH were found to be within normal limits. But TSH values in remission were significantly elevated compared to the first episode.

Conclusions: Thyroid profiles in control were within normal range. The T4 and T3 levels in nephrotic syndrome were low and TSH was high. Hypothyroidism was more common in children less than 6 years. 


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