Evaluation of serum lipid profile in children with nephrotic syndrome admitted in emergency ward of Government Tirunelveli Medical College and Hospital, India

C. Krishanamurthy, J. Rukmani, Denny Clarin


Background: Nephrotic syndrome is a collection of clinical findings due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant edema. The objective of this study was to study the correlation between lipid profile and different types of nephrotic syndrome

Methods: This cross-sectional study was done between March 2017 - October 2017 in the Department of Pediatrics, Tirunelveli Government Medical College. 40 cases of nephrotic syndrome between 1 to 12 years, which include all types of nephrotic syndrome. After history taking and clinical examination, blood samples were collected from the patients for lipid profile and analyzed with standard techniques.

Results: In the 40 cases included in the present study mean serum albumin was low (mean = 2.212 gm %), mean total cholesterol (mean = 344.300 mg/dl) mean triglycerides (mean = 304.025 mg/dl) mean LDL (mean = 234.650 mg/dl) and mean VLDL (mean = 61.625 mg/dl) were elevated. HDL (mean = 46.07 mg/dl) with in normal limits. No significant changes observed.

Conclusions: Serum cholesterol levels elevated significantly in relapse cases compared to the first episode. Serum cholesterol in SRNS cases shows statistically significant elevation compared to other types. LDL values were elevated in relapse cases compared to the first episode which were found out to be statistically insignificant. LDL values in SRNS cases show statistically significant elevation compared to first episodes and SDNS cases.


Lipid profile, Nephrotic syndrome, Steroid-Resistant Nephrotic Syndrome (SRNS), Steroid-Dependent Nephrotic Syndrome (SDNS)

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Afroz S, Khan AH, Roy DK. Thyroid function in children with nephrotic syndrome. Mymensingh Med J. 2011;20(3):407-11.

Bhandari, Mandowara SL. Lipoprotein profile in nephrotic syndrome. Indian Pediatr. 1980;17:416-9.

Carrie BJ, Salyer WR, Myers BD. Minimal change nephropathy: an electrochemical disorder of the glomerular membrane. Am J Med. 1981;70:262.

Clark AG, Barratt TM. Steroid-responsive nephrotic syndrome. In: Barratt TM, Avner ED, Harmon, eds. Pediatric Nephrology. Baltimore: Lippincott, Williams & Wilkins; 1998:731-4.

Thomas EM, Rosenblum AH, Lander HB, Fisher R. Relationship between blood lipid and blood protein levels in nephrotic syndrome. Am J Dis Child. 1951;(81):207.

Iglesias P, Diez JJ. Thyroid dysfunction and kidney disease. Eu J Endocrinol. 2009;160:503.

Peters JP, Man EB. The interrelationship of serum lipids in patients with diseases of kidneys. J Clin Invest. 1943;22:721.

Katz AI, Emmanouel DS, Marshall DL. Thyroids hormone and the kidney. Nephron. 1975;15:223-49.

Kitano Y, Yoshikawa N, Nakamura H. Glomerular anionic sitesin minimal change nephrotic syndrome, and focal segmental glomerulosclerosis. Clin Nephrol. 1993;40:199.

Krishnaswamy D, Indumati V, Satihkumar D, Vijay V, Maharudra S, Amareshwara M, Rajeshwari V. Serum proteins, initial and follow-uplipid profile in children with nephrotic syndrome. IJABPT 2011;2:59-63.

Levin M, Smith C, Walters MD. Steroid-responsive nephrotic syndrome: a generalized disorder of membrane negativecharge. The lancet. 1985;326(8449):239-42.

Niaudet P, Gagnadoux MF, Broyer M. Treatment of the childhood steroid-resistant idiopathic nephrotic syndrome. Adv Nephrol Necker Hosp. 1998;28:43.

White RH, Glasgow EF, Mills RJ. Clinicopathological study of nephrotic syndrome in childhood. Lancet. 1970;295(7661):1353-9.

Niaudet P. Steroid sensitive idiopathic nephrotic syndrome inchildren. In: Avner ED, Harmon WE, eds. Pediatric Nephrology. Philadelphia: Williams and Wilkins; 2004:543-547.

Schussler GC. The thyroxine-binding proteins. Thyroid. 2000;10:141-9.

International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. Pediatr. 1981;98:561-4.

Yokoyama H, Kida H, Abe T. Impaired immunoglobulin production in minimal change nephrotic syndrome in adults. Clin Exp Immunol. 1987;70:110.

Niaudet P. Steroid sensitive idiopathic nephrotic syndrome in children. In: Avner ED, Harmon WE, eds. Pediatric Nephrology. Philadelphia: Williams and Wilkins; 2004:54325.

Shalhoub RJ. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet. 1974;304(7880):556-60.

Sasdelli M, Cagnoli L, Candi P. Cell-mediated immunity idiopathic glomerulonephritis. Clin Exp Immunol. 2005;46:27