Antibiotic resistance pattern of uropathogens in urinary tract infections in children at State Referral Hospital, Falkawn, Mizoram, India


  • F. Elizabeth Lalhmangaihzuali Department of Pediatrics, Mizoram Institute of Medical Education and Research (MIMER), Falkawn, Aizawl, Mizoram, India
  • Zarzoliana . Department of Geography, Government Hrangbana College, Aizawl, Mizoram, India
  • Zorinsangi Varte Department of Medicine, Mizoram Institute of Medical Education and Research (MIMER), Falkawn, Aizawl, Mizoram, India
  • Gracy Laldinmawii Department of Microbiology, Mizoram Institute of Medical Education and Research (MIMER), Falkawn, Aizawl, Mizoram, India



Antibiotic, Resistance, Susceptibility, Urinary Tract Infection, Uropathogens


Background: Analysing antibiotic susceptibility pattern of uropathogens help to overcome the therapeutic difficulties created by the rising anti-microbial resistant bacteria and guides in choosing appropriate antibiotics. Hence, we aimed at evaluating the uropathogens causing urinary tract infections and study their antibiograms.

Methods: Midstream urine samples were collected, cultured and appropriate biochemical tests were performed for proper identification of urinary tract pathogens in State Referral Hospital Falkawn, Mizoram, India from 1st January to 30th June 2018.

Results: The most common isolated gram-negative uropathogens were Escherichia coli (40.9%), followed by Klebsiella spp. (17.6%), Proteus spp. (10.7%) and Pseudomonas spp. (3.1%). Among gram-positive organisms Enterococcus spp. (20.1%) and Staphylococcus spp. (7.6%) were grown. Urinary tract infections were more prevalent in girls (64.8%) than boys (35.2%). High level of resistance was found to amoxycillin/ampicillin by all the organisms isolated.

Conclusions: Almost all the test organisms exhibited multiple antibiotic resistance. The study identified multiple antibiotics resistance by uropathogens which were earlier used as first line of treatment of UTI in children.


Chang SL, Shortliffe LD. Pediatric urinary tract infections. Pediatr Clin North Am. 2006;53(3):379-400.

Choi da M, Heo TH, Yim He, Yoo Kh. Evaluation of new American Academy of Pediatrics guideline for febrile urinary tract infection. Korean J Pediatr. 2015;58:341-6.

Karen JM, Robert MK, Om PM, Shakuntala SP, Surjit S. Nelson Essentials of Pediatrics, 1st South Asia Edition. Elsevier India; 2016:376.

Ronald A. The etiology of urinary tract infection: Traditional and emerging pathogens. Am J Med. 2002;113(1A):14S-19S.

Wilson ML, Gaido L. Laboratory Diagnosis of Urinary Tract Infections in Adult Patients. Clin Infect Dis. 2004;38:1150-8.

Bonadio M, Meini M, Spetaleri P, Gilgi C. Current microbiological and clinical aspects of urinary tract infections. Eur J Urol. 2001;40:439-45.

Grude N, Tveten Y, Kristiansen BE. Urinary tract infections in Norway: bacterial etiology and susceptibility, a retrospective study of clinical isolates. Clin Microbiol Infect. 2001;7:543-7.

Farrell DJ, Morrissey I, Rubeis DD, Robbins M, Felmingham DA. A UK multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infection. J Infect. 2003;46(2):94-100.

Mathai D, Jones RN, Pfaller MA. Epidemiology and frequency of resistance among pathogens causing urinary tract infection in 1,510 hospitalized patients: a report from the sentry Antimicrobial Surveillance Program (North America). Diag Microbial Infect Dis. 2001;40:129-36.

Kavitha J, Arvind MA, Jayachandran G, Priya. Risk factors for urinary tract infection in paediatric patients. Int J Contemp Pediatr. 2018;5:184-9.

Sanjida KS, Abu NIS, Ahmed AS, Chandan KR, Mushtaque A, Muhammadullah S, et al. Study of Bacterial pathogens in Urinary Tract Infection and their antibiotic resistance profile in a tertiary care hospital of Bangladesh. Bangladesh J Med Microbiol. 2016;10(01):22-6.

Mallla KK, Sharma MS, Malla T, Thapalial A. Clinical profile, bacterial isolates and antibiotic susceptibility pattern in urinary tract infection in children -hospital based study. J Nepal Pediatr Society. 2008;28:52-61.

Akram M, Shahid M, Khan AU. Etiology and antibiotic resistance patterns of community- acquired urinary tract infections in JNMC Hospital Aligarh, India. Ann Clin Microbiol Antimicrobials. 2007;6:4.

Bouskroui M, Ait SI, Draiss G, Bourrous M, Sbhi M. Epidemiology of urinary tract infection in children in Marrakech. Arch Pediatr. 2010;17: 5177-8.

Sumit G, Reshma A, Suneel B, Arti A, Ankur G. Urinary tract infection in paediatrics patients in north India, J Dent Med Sci. 2013;11(3):58-62.

Vishal K, Sanjata RC. Study for prevalence of urinary tract infection(uti) in febrile children and to assess of validity of microscopic urine analysis in diagnosis of UTI. Int J Contem Med Res. 2017;4(4):826-9.

Wazait HD, Patel HR, Veer V, Kelsey M, Van DM. Catheter- associated urinary tract infections: prevalence of uropathogens and pattern of antimicrobial resistance in a UK hospital. BJU. 2003;91:806-9.

Rekha T, Gurudas K, Nupur S, Ajeet KK. Antibiotic sensitivity pattern of pathogens in children with urinary tract infection in a tertiary care hospital in Kachchh, Gujarat, India. Int J Contemp Pediatr. 2017;4(6):2103-8.

Adjei O, Opoku C. Urinary tract infections in African infants. Int J Antimicrob Agents. 2004;24(1):S32-34.

Allen UD, Mac Donald N, Fuite L, Chan F, Stephen D. Risk factors for resistance to ‘first – line’ antimicrobials among urinary tract isolates of Escherichia coli in children. CMAJ. 1999;160:1436-40.

Haller M, Brandis M, Berner R. Antibiotic resistance of urinary tract pathogens and rationale for empherical intravenous therapy. Pediatr Nephrol. 2004;19:982-6

Ladhani S, Gransden W. Increasing antibiotics resistance among urinary tract isolates. Arch Dis Child. 2003;88:444-5.

Paris D, Straussberg R, Avitzur Y, Nussinovitch M, Harel I, Amir J. Bacterial susceptibility to oral antibiotics in community acquired urinary tract infection. Arch Dis Child. 2003;88:215-8.

Carapetis JR, Jaquiery AL, Buttery JP. Randomized, controlled trial comparing once daily and three times daily gentamicin in children with urinary tract inferctions. Pediatr Infect Dis J. 2001;20:240-6.

Marwan O, Hassan M, Monzer H, Elie BR. Prevalence and antibiotic susceptibility patterns of bacteria causing urinary tract infections in Youssef Hospital Center: first report from Akkar governorate, North Lebanon. Int Arabic J Antimicrobial Agents. 2017;7(1):2-10.






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