Incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates in Ardabil City

Majid Vafaie; Mehrdad Mirzarahimi; Saeid Sadeghieh-Ahari; Afsaneh Enteshari-moghaddam; Hadi Merrikhi

doi:10.18203/2349-3291.ijcp20184295

Authors

Majid Vafaie Department of Pediatrics, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Mehrdad Mirzarahimi Department of Pediatrics, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Saeid Sadeghieh-Ahari Department of Community Medicine, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Afsaneh Enteshari-moghaddam Department of Internal Medicine, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Hadi Merrikhi Department of General Practionaire, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran

DOI:

https://doi.org/10.18203/2349-3291.ijcp20184295

Keywords:

Hyperbilirubinemia, Jaundice, Newborn, Phototherapy, Platelet count

Abstract

Background: Jaundice is one of the most common problems in neonatal period. In 60% of term and 80% of preterm neonates are seen during the first week of birth and most cases are physiologic. Hyperbilirubinemia is the most common cause of jaundice in newborns. Phototherapy is used to treat it, which seems to be safe. Some studies showed that thrombocytopenia is one of the side effects of phototherapy. The aim of this study was to investigate the relationship between thrombocytopenia and phototherapy in newborns.

Methods: This is a descriptive study that has been done on 100 neonates with jaundice which requiring phototherapy. A blood sample was taken at the admission time, 24 hours late, end of the phototherapy and 48 hours after the end of phototherapy to measure the bilirubin and the number of platelets along with other necessary tests for the study of hyperbilirubinemia. Data collected by a checklist and analyzed by statistical methods in SPSS version 19.

Results: Of all neonates, 55% were boy and 45% were girl with mean age of 8.86 days. The mean platelet count before phototherapy, 24 hours late, at the end of phototherapy, and 48 hours after phototherapy were 298170, 288540, 282620 and 266310, respectively which was statistically significant during time.

Conclusions: The results of this study showed that phototherapy can lead to a significant reduction in platelet count in newborns. Also, there wasn’t seen any case of thrombocytopenia following phototherapy in the present study.

Metrics

Metrics Loading ...

References

Hyperbilirubinemia SO. Practice parameter: management of hyperbilirubinemia in the healthy term newborn. Pediatrics. 1994;94(4):558-65.

Bergman L. Plasma calcium fractions during the first days of life with special reference to neonatal hypocalcaemia. Neonatology. 1972;20(5-6):346-59.

Sharafi R, Mortazavi Z, Sharafi S, Parashkouh RM. The effect of clofibrate on decreasing serum bilirubin in healthy term neonates under home phototherapy. Iranian J Pediatr. 2010;20(1):48.

Bert S, Gouyon JB, Semama DS. Calcium, sodium and potassium urinary excretion during the first five days of life in very preterm infants. Neonatology. 2004;85(1):37-41.

Ozkaya O, Buyan N, Erol I, Atalay Y, Beyazova U, Sahin F, Söylemezoğlu O. The relationship between urinary calcium, sodium, and potassium excretion in full-term healthy newborns. Turkish J Pediatr. 2005;47(1):39-45.

Eghbalian F, Monsef A. Phototherapy-induced hypocalcemia in icteric newborns. Iranian J Med Sci. 2015;27(4):169-71.

Aspberg, Sara, Dahlquist, Gisela, Kahan, Thomas, Källén, Bengt. Is neonatal phototherapy associated with an increased risk for hospitalized childhood bronchial asthma? Pediatric allergy and immunology, 2007;18(4):313-9.

Basiglio CL, Arriaga SM, Pelusa F, Almara AM, Kapitulnik J, Mottino AD. Complement activation and disease: protective effects of hyperbilirubinaemia. Clinical Science. 2009;118(2):99-113.

Ahlfors CE, Predicting bilirubin neurotoxicity in jaundiced newborns. Current opinion in pediatrics. 2010;22(2):129-33.

Khera S, Gupta R. Incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates. Med J Armed Forces India. 2011;67(4):329-32.

Pishva N, Pishva H. Incidence of thrombocytopenia in hyperbilirubinemic neonates during phototherapy. Acta Medica Iranica. 2000;38(1):7-9.

Shahian M, Rashtian P, Kalani M. Unexplained neonatal jaundice as an early diagnostic sign of urinary tract infection. Int J Infect Diseases. 2012;16(7):e487-e90.

Ghaffarpour SK, Sultani H. Effect of phototherapy on platelet and white blood cell count in term infanats. 2006;39(1):79-89.

Lucey J, Ferreiro M, Hewitt J. Prevention of hyperbilirubinemia of prematurity by phototherapy. Pediatrics. 1968;41(6):1047-54.

Sakha K, Sultani H. The prophylactic effect of lactulose on neonatal hyperbilirubinemia by acceleration of meconium passage. Med J Islam Repub Iran. 2002;16(3):151-4.