A study of clinico-immunological response to art in HIV infected children in western Rajasthan
Keywords:Adherence, ART therapy, Immune response, Pediatric HIV
Background: Study of clinico immunological response to antiretroviral drugs in HIV infected children.
Methods: 50 HIV positive children after immunological categorization put on first line pediatric ART treatment according to pediatric ART NACO guideline, side effect, clinical response (in the form of change of WHO clinical staging), and immunological response (in the form of change of CD4 count, and immunological staging) were noted on follow up study.
Results: The Correlation between WHO clinical staging and immunological staging was poor so initiating anti retro viral treatment should be preferably based on CD4 count. Children who were initiated on ART have a significant improvement in both WHO clinical and immunological staging at the six and twelve months follow up and ART found to be well tolerated.
Conclusions: Significant clinical and immunological improvement occur in the children who were put on ART based on CD4 counts provided if the adherence level is very good.
India: NACO Newsletter. 2006;2(4):27-30. Available from: http://www.nacoonline.org.
Park K. AIDS. In: K. Park editor. Park’s Text Book of Preventive and Social Medicine 20th edition. India: Bhanot Publishers. 2013:316-28.
Towards Universal Acess: scalling up priority HIV/AIDS Interventions in the health sector. Geneva; 2009:4-7. Available from: http//www.who.int/hiv.
India: NACO Newsletter. 2009;5(1):4-5. Available from: http://www. nacoonline. Org.
India: Rajasthan state AIDS Controll society Update. 2007. Available from: http//www.rsacs. in/hiv/html.
Yogev R, Chadwic EG. Acquired Immunodeficiency Syndrome. In: Robert M Kliegman, Bonita F. Stanton, Josef W. St Geme lll and Nina F. schor, editors. Nelson Textbook of Peditrics. 20th Edison. India: Elsevier. 2016:1645-66.
Udgirkar VS, Tullu MS, BavdekarSB, ShaharaoVB, Kamat JR, Hira PR. Nerological mainifestations of HIV infection. Indian Pediatr. 2003;40:230-4.
Bohjanen PR, Boulware DR. Immune reconstitution inflammatory syndrome. In: Volberding P, Sande MA, Lange J, Greene W, Editors. Global HIV/AIDS Medicine. Philadelphia: Elsevier. 2007:193-205.
Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, Whiite JR, Hamill RJ. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. Aids. 2005;19:399-406.
Agarwal D, chakravarty J, Sundar S, Gupta V, Bhatia BD. Correlation between clinical features and degree of immunosuppression in HIV infected children. Indian Pediatr. 2008;45:140-3.