Hypothyroidism presenting with development delay, failure to thrive, and pituitary adenoma
DOI:
https://doi.org/10.18203/2349-3291.ijcp20173809Keywords:
Congenital hypothyroidism, Pituitary adenomaAbstract
Pituitary enlargement secondary to primary hypothyroidism (PH) is a known but uncommon occurrence, and is also difficult to distinguish on CT and MRI from primary pituitary tumors. Following adequate hormone replacement with L-thyroxine, both symptoms and pituitary hyperplasia are reported to regress within a few months. It is important to recognize this condition so as to avoid unnecessary surgery.
References
Moltz KC, Postellon DC. "Congenital hypothyroidism and mental development". Compr Ther. 1994;20(6):342-6.
Van Vliet G, Deladoëy J. Disorder of the thyroid in the newborn and infant. In: Sperling MA, ed. Pediatric Endocrinology. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:7.
Ashley WW, Ojemann JG, Park TS, Wippold FJ. Primary hypothyroidism in a 12-year-old girl with a suprasellar pituitary mass: rapid regression after thyroid replacement therapy: case report. J Neurosurg. 2005;102:413-6.
Khawaja NM, Taher BM, Barham ME, Naser AA, Hadidy AM, Ahmad AT. Pituitary enlargement in patients with primary hypothyroidism. Endocr Pract 2006;12:29-34.
Radiana S, Coculescua M, Morriss JF. Somatotroph to thyrotroph cell transdifferentiation during experimental hypothyroidism- a light and electron-microscopy study. J Cell Mol Med. 2003;7:297-306.
Joshi AS, Woolf PD. Pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature. Pituitary. 2005;8:99-103.
Alkhani AM, Cusimano M, Kovacs K, Bilbao JM, Horvath E, Singer W. Cytology of pituitary thyrotroph hyperplasia in protracted primary hypothyroidism. Pituitary. 1999;1:291-5.
Nicholas WC, Russell WF. Primary hypothyroidism presenting as a pituitary mass. J Miss State Med Assoc. 2000;41:511-4.
Hopper NW, Albanese A. Primary hypothyroidism in a child mimicking a pituitary macroadenoma. Horm Res. 2005;63:61-4.
Papakonstantinou O, Bitsori M, Mamoulakis D, Bakantaki A, Papadaki E, Gourtsoyiannis N. MR imaging of pituitary hyperplasia in a child with growth arrest and primary hypothyroidism. Eur Radiol. 2000;10:516-8.
