Published: 2016-12-21

Assessment of developmental outcome of neonatal seizures at NICU of tertiary care centre hospital

Swati Saral, Pawan Ghanghoria


Background: Seizures are relatively common among first month of life. New-born with neonatal seizures are at risk of developmental delay. The objective of this study was to assess the developmental outcome of neonatal seizures and to study the factors associated with delayed developmental outcome in neonatal seizures.

Methods: A prospective observational Study was conducted in 71 term and preterm neonates with documented seizure admitted in Medical college hospital, Jabalpur. A predesigned pretested questionnaire was used. The face to face interview technique was used for collection of data by mother, followed by clinical examination of newborn and investigations were done. DDST II was used for developmental assessment of neonates.

Results: Neonates with delayed developmental outcome are 42.62%. Delayed developmental outcome is significantly associated with male sex, low birth weight, prematurity and multiple frequencies of seizures.

Conclusions: The delayed developmental outcome was high among neonatal seizures. 


Development delay, Neonate, Seizure

Full Text:



Cloherty JP, Eichenwald EC, Hansen AR, Stark AR. Manual of Cloherty 7th Edition. Manual of neonatal care. Lippincott Williams and Wilkins. Chapter 56 Neonatal Seizures; 2008:729-42.

Panayiotopoulos CP. The epilepsies - seizure, syndrome and management. 2005;5:118-29.

Volpe JJ. Neonatal seizures: current concepts and revised classification. Pediatrics. 1989;84(3):422-8.

Nair MKC. Developmental assesment. Growth and development. Dilip Mukherjee and MKC Nair. 1st ed. New Delhi: Jaypee Brothers Medical Publishers LTD; 2008:206.

Iype M, Prasad M, Nair PM, Geetha S, Kailas L. The newborn with seizures - a follow-up study. Indian Pediatr. 2008;45(9):749-52.

Mwaniki M, Mathenge A, Gwer S, Mturi N, Bauni E, Newton CR, et al. Neonatal seizures in a rural Kenyan District Hospital: aetiology, incidence and outcome of hospitalization. BMC Medicine. 2010;8(1):16.

Mizrahi EM, Kellaway P. Diagnosis and management of neonatal seizures. Raven Press; 1998.

Fernandes LV, Goulart AL, dos Santos AM, Barros MC, Guerra CC, Kopelman BI. Neurodevelopmental assessment of very low birth weight preterm infants at corrected age of 18-24 months by Bayley III scales. J Pediatr (Rio J). 2012;88:471-8.

Vohr BR, Wright LL, Dusick AM, Perritt R, Poole WK, Tyson JE, et al. Center differences and outcomes of extremely low birth weight infants. Pediatrics. 2004;113(4):781-9.

Pisani F, Sisti L, Seri S. A scoring system for early prognostic assessment after neonatal seizures. Pediatrics. 2009;124(4):e580-7.

Brunquell PJ. EEG is a useful predictor of seizure recurrence following withdrawal of anticonvulsant medication in children. J Epi. 1991;4(1):3-7.

Iida K, Takashima S, Takeuchi Y. Etiologies and distribution of neonatal leukomalacia. Pediatr Neurol. 1992;8(3):205-9.

Levene MI, Fawer CL, Lamont RF. Risk factors in the development of intraventricular haemorrhage in the preterm neonate. Arch Dis Child. 1982;57(6):410-7.

Rosenblith JF, Sims-Knight JE. In the beginning: development in the first two years of life. Thomson Brooks/Cole Publishing Co; 1985.

Sankar JM, Agarwal R, Deorari A, Paul VK. Management of neonatal seizures. Indian J Pediatr. 2010;77(10):1129-35.