Reduced serum calcium is a risk factor for febrile seizures


  • Ushakiran C. B. Department of Pediatrics, MMCRI, Mysore, Karnataka, India
  • Suresh R. Department of Pediatrics, MMCRI, Mysore, Karnataka, India



Electrolytes, Febrile seizure, Risk factor, Serum calcium



Background: Febrile seizure (FS) is the most common cause of convulsions in children. The objective of present work was to study the association between serum electrolytes and febrile seizures.

Methods: Children in the age group of 6 month to 6 years with febrile seizures satisfying inclusion criteria and equal number of age and sex matched controls were subjected to estimation serum electrolytes and compared using appropriate statistical methods.

Results: Serum Calcium levels in children with febrile seizures were reduced and this observation was statistically significant.

Conclusions: Definite association was found between serum calcium levels and the occurrence of febrile seizures. Although serum calcium levels were not in the hypocalcemic range, they were decreased enough to cause a statistical significance in precipitating febrile seizures. 


Vestergaard M, Obel C, Henriksen TB, Christensen J, Madsen KM, Ostergaard JR, et al. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J Clin Epidemiol. 2006;59:61-6.

Mohammed A. Mikati. Seizures in Childhood. Behrman RE, Kleigman RM, editors, Nelson Textbook of Pediatrics 19th edition Philadelphia: Saunders. 2011;586:2013-18.

Veena Kalra. Febrile Convulsions. In: Ghai OP, Gupta P, Paul VK, editors. Ghai Essential Pediatrics.7th ed. New Delhi: CBS Publishers and Distributors; 2004:528.

Indhu Khurana. Essentials of Medical Physiology. India; Elsevier; 2008:434-47.

Chiarelli F, De Palma C, Verrotti A, Lombardi G, Domizio S: Electrolytic changes in febrile convulsions. Pediatr Med Chir. 1985;7(2):249-52.

Akbayram S, Cemek M, Büyükben A, Aymelek F, Karaman S, Yilmaz F et al. Major and minor bio-element status in children with febrile seizure. Bratisl Lek Listy. 2012;113(7):421-3.

Rutter N. and Smales ORC. Calcium, magnesium, and glucose levels in blood of children with febrile convulsions. Archives Dis Childhood. 1976;51:141.

Sakha K, Barzar M. Evaluation of Serum Sodium and Ionized Calcium Levels in Febrile Convulsions. Pediatr Med Chir. 1985;7(2):249-52.

Sayedzadeh SA, Hemati M. Serums Sodium and Calcium Level in Children with Simple and Recurrent Febrile Convulsion. J Comprehens Pediatr. 2013;3(5):179-83.

Papierkowski A, Mroczkowska-Juchkiewicz A, Pawłowska-Kamieniak A, Pasternak K. Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions. Pol Merkur Lekarski. 1999;6(33):138-40.

Fallah R, Islami Z. Evaluation of Serum Sodium Levels in Simple, Multiple and Recurrent Febrile Convulsions. J Acta Medic Iran. 2009:47(3):225-7.

Jayashree NJ, Ila Binaykiya, Sharma U, Dwivedi R. Role of serum sodium levels in prediction of seizure recurrence within the same febrile illness. Neurol Asia. 2011;16(3):195-7.

John E, Guyton, Hall. Text book of medical physiology.13thed. Philadelphia: Saunders/ Elsiever; 2010:116.

Zoethout WD, Zoethout WT. Text book of physiology.12th ed. St Louis Mosby; 1952:420-1.






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