Prevalence of hepatitis A virus as cause of acute viral hepatitis in central Karnataka, India
Keywords:Acute viral hepatitis, Anti-HAV IgM, Hepatitis A virus, Central Karnataka, Immunochromatograhic assay
Background: Hepatitis A is a preventable infectious disease with global distribution. Knowledge about the epidemiology of hepatitis A in a particular region will helpful for appropriate management of cases as well as preventive strategies for that region or area could be planned. The aim of the present study was to determine the prevalence of hepatitis A virus (HAV) as cause of acute viral hepatitis (AVH) in Central Karnataka, India.
Methods: Blood samples were collected from AVH cases over a period of six months from June 2015 to November 2015 among patients attending a tertiary care centre, Davangere, Karnataka, India. Samples were tested for HAV IgM antibody (anti-HAV IgM) using a commercially available immunochromatographic assay.
Results: Out of 51 samples tested, 19 (37.25%) were positive for anti-HAV IgM. Seropositivity for HAV was higher in females (43.75%) than males (34.29%). Agewise anti-HAV IgM positivity showed highest rate in 1-5 years age group (50.0% ), followed by 6-10 years group (42.86%) with a decline in older age groups (> 15 years).
Conclusions: HAV causes AVH most commonly in early childhood and a small number of adolescents and adults. Females are more commonly infected than males. The preventive strategies and control measures of hepatitis A will be determined by future definition of HAV epidemiology in the Central Karnataka region, India.
Joon A, Rao P, Shenoy S M, Baliga S. Prevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) in the patients presenting with acute viral hepatitis. Indian J Med Microbiol. 2015;33:102-5.
Radhakrishnan S, Raghuraman S, Abraham P, Kurian G, Chandy G, Sridharan G. Prevalence of enterically transmitted hepatitis viruses in patients attending a tertiary – care hospital in South India. Indian J Pathol Microbiol. 2000;43:433-6.
Melhem NM, Jaffa M, Zaatari M, Awada H, Salibi NE, Ramia S. The changing pattern of hepatitis A in Lebanese adults. Int J Infect Dis. 2015;30:87-90.
Acharya SK, Madan K, Dattagupta S, Panda SK. Viral hepatitis in India. National Med J India. 2006;19:203-17.
Jain P, Prakash S, Gupta S, Singh KP, Shrivastava S, Singh DD, et al. Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: a hospital based study. Indian J Med Microbiol. 2013;31:261-5.
Syed R, Mohammed AH, Sindiri PK, Nathani AA, Rao VVR, Satti VP, et al. Seroepidemiology of hepatitis A virus in Hyderabad, South India. J Med Allied Sci. 2012;2:58-61.
Arankalle V, Mitra M, Bhave S, Ghosh A, Balasubramanian S, Chatterjee S, et al. Changing epidemiology of hepatits A viris in Indian children. Vaccine Develop Ther. 2014;4:7-13.
Kar P. Is there a change in seroepidemiology of hepatitis A infection in India? Indian J Med Res. 2006;123:727-9.
Poddar U, Thapa BR, Prasad A, Singh K .Changing spectrum of sporadic acute viral hepatitis in Indian children. J Trop Pediatr. 2002;48:210-3.
Villar LM, Paula VS, Gaspar AM. Seasonal Variation of Hepatitis A virus infection in the city of rio de Janeiro. Brazil Rev Inst Med Trop S Paulo. 2002;44:289-92.
Naaimi AS, Turky AM, Khaleel HA, Jalil RW, Mekhlef OA, Kareem SA, et al. Predicting acute viral hepatitis serum markers (A and E ) in patients with suspected acute viral hepatitis attending primary health care centers in baghdad :a one year cross-sectional study. Global J Health Sci. 2012;4:172-83.
Aggarwal R, Naik S, Yachha SK, Naik SR. Seroprevalence of antibodies to hepatitis a virus among children in northern India. Indian Pediatrics. 1999;36:1248-50.
Rashed ARS. Prevalene of hepatitis A virus among Saudi Arabian children: a community-based study. Ann Saudi Med. 1997;17:200-3.
Mall ML, Rai RR, Philip M, Naik G, Parekh P, Bhawnani SC, et al. Seroepidemiology of hepatitis A infection in India: changing pattern. Indian J Gastroenterol. 2001;20:132-5.
Batra Y, Bhatkal B, Ojha B, Kaur K, Saraya A, Panda SK, et al. Vaccination against hepatitis A virus may not be required for school children in northern India: results of a seroepidemiological survey. Bull World Health Organ. 2002;80:728-31.
Alhan E, Kozanoglu B, Tumgor G, Celik U, Yaman A, Bozdemir N. Epidemiological shift of hepatitis A in central Adana, Turkey. Turk J Gastroenterol. 2014;25(1):6-8.