DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20164014

Effect of perinatal asphyxia on thyroid stimulating hormone and thyroid hormone levels in a rural tertiary care center in Mandya district of Karnataka, India

Sunil Kumar P., Haricharan K. R., Venugopala K. L.

Abstract


Background: Studies have shown a difference between serum concentrations of TSH, T4, T3 and FT4 in asphyxiated newborns than in normal newborns which suggesting abnormal thyroid function in asphyxia. We planned this study to assess and compare the effect of perinatal asphyxia on thyroid stimulating hormone and thyroid hormone levels.

Methods: This was a tertiary care teaching hospital based, prospective case control study conducted on normal full term and full term asphyxiated neonates delivered and admitted in the neonatal intensive care unit at Adichunchanagiri Institute of Medical Sciences, B. G. Nagara, Karnataka, India from December 2012 to May 2014.

Results: The means for thyroid hormones, in cord blood, were similar in both groups, except rT3are higher for non-asphyxiated new born as compared to asphyxiate ones. In newborns with 18-24 hours of life, lower levels of T4, T3, FT4, and TSH were observed in asphyxiated newborns, in which the basal levels (in cord blood) with exception of FT4, failed to increase.

Conclusions: Our study suggests that lower T4, free T4, and T3 levels are secondary to lower TSH levels in asphyxiated newborns; also, peripheral metabolism of T4 in asphyxiated infants can be altered due to low T3 and normal reverse T3 levels. 


Keywords


Asphyxia, TSH, Thyroid hormone levels

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