Antibiotics in children with bronchial asthma


  • Safal Muhammed Department of Pediatrics, Armed Forces Medical College, Pune, Maharashtra, India
  • Deepak Joshi Department of Pediatrics, Armed Forces Medical College, Pune, Maharashtra, India



Childhood asthma, Empirical antibiotics, Mild to moderate exacerbations


Background: This study was conducted to determine if oral antibiotics started at presentation reduce the duration of acute exacerbations of bronchial asthma by comparing the durations of mild to moderate exacerbations of asthma managed with or without antibiotics in children below 12 years.

Methods:In this systematic trial, we allocated the eligible children to antibiotic group (who also received standard of care and control (the standard of care) group (n=40 in each group) and compared the duration of acute asthma exacerbation between the two groups.

Results: The mean difference of duration of mild and moderate exacerbations between the antibiotic and control group was 4.76 hours (95% Confidence Interval (CI) of -36.76 to 28.84) which was found not to be statistically significant (p value- 0.482).

Conclusions:There was no significant reduction in the duration of mild to moderate exacerbations of asthma in children below 12 years by the administration of empirical antibiotics.


Global Strategy for Asthma Prevention and Management, Global Initiative for Asthma; 2015.

Liu AH, Covar RA, Spahn JD and Sicherer SH. In: Kliegman, Stanton, St Geme and Schor. Nelson Textbook of Pediatrics. 20th edition. Philadelphia: Elsevier; 2015.

Huang YJ. Asthma microbiome studies and the potential for new therapeutic strategies. Curr Allergy Asthma Rep. 2013;13(5):453-61.

Xepapadaki P, Koutsoumpari I, Papaevagelou V, Karagianni C, Papadopoulos NG. Atypical bacteria and macrolides in asthma. Allergy Asthma Clin Immunol. 2008;4(3):111-6.

Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, et al. Viruses and bacteria in acute asthma exacerbations--a GA2 LEN-DARE systematic review. Allergy. 2011;66(4):458-68.

Bisgaard H, Hermansen MN, Bønnelykke K, Stokholm J, Baty F, Skytt NL, et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ. 2010;341:4978.

Thumerelle C, Deschildre A, Bouquillon C, Santos C, Sardet A, Scalbert M, et al. Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: a prospective study in the Nord-Pas de Calais region (France). Pediatr Pulmonol. 2003;35(2):75-82.

Friedman R, Ackerman M, Wald E, Casselbrant M, Friday G, Fireman P. Asthma and bacterial sinusitis in children. J Allergy Clin Immunol. 1984;74(2):185-9.

Global Strategy for Asthma Prevention and Management, Global Initiative for Asthma; 2012.

Jindal SK, Aggarwal AN, Gupta D, Agarwal R, Kumar R, Kaur T, et al. Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). Int J Tuberc Lung Dis. 2012;16(9):1270-7.

Shapiro GG, Eggleston PA, Pierson WE, Ray CG, Bierman CW. Double-blind study of the effectiveness of a broad spectrum antibiotic in status asthmaticus. Pediatrics. 1974;53(6):867-72.

McCallum GB, Morris PS CA. Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. Cochrane database Syst Rev. 2012;12:9834.

Kozyrskyj AL, Dahl ME, Ungar WJ, Becker AB, Law BJ. Antibiotic treatment of wheezing in children with asthma: what is the practice? Pediatrics. 2006;117(6):1104-10.






Original Research Articles