Prediction of relapses in children with idiopathic steroid sensitive nephrotic syndrome: a retrospective study


  • Prasun B. Department of Pediatrics, Sharda School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India
  • Payas J. Department of Pediatrics, Sharda School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India
  • Sujaya M. Department of Pediatrics, Sharda School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India



Children, Nephrotic syndrome, Predictors, Relapse


Background: Nephrotic syndrome is a chronic recurrent disease commonly affecting children belonging to the age group 1-10 years. The purpose of the study was to identify the factors at the onset of disease responsible for relapses in nephrotic syndrome.

Methods: It was a retrospective observational study conducted in a tertiary care hospital in North India consisting of children aged 1-15 years diagnosed as nephrotic syndrome (1st episode) and followed for 12 months. Variables extracted from records (after January 2008) were age of presentation, days to remission, hematuria, and hypertension.

Results: Out of 88 cases, 23 were frequent relapsers and 65 were infrequent relapsers. It was observed that cases remitting after 2 weeks have increased chances of frequent relapses. On stratification based on presence or absence of hematuria or hypertension, it was observed that both these variables predispose the patient towards frequent relapses.

Conclusions: We concluded that variables like days to remission, haematuria and hypertension can fairly predict future relapses.


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Original Research Articles