A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

Pragalatha kumar, Aruna Gowdra, Arathi Arathi, Ananya Sampath


Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.

Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.

Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).

Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  


Children, Serum vitamin D levels, Severity of Asthma

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Liu AH, Covar RA et al. Childhood Asthma: In: Kleigman, Stanton, St Geme, Schor, (eds.) Nelson Text Book of Pediatrics. 20th Ed. Philadelphia: Elsevier; 2015:1095-1115.

Zhang R, Naughton DP. Vitamin D in health and disease: current perspectives. Nutrition J. 2010 Dec 8;9(1):65.

Maosoli M, Fabian D, Holt S, Beasley R. Global initiative for asthma (GINA) Program. The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy. 2004;59:469-78.

Brehm JM, Celedon JC, Sotos-Quiros ME, Avila L, Hunninghake GM, Fomo E et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765-71.

Elnadya HG, Foudac EM, Elsheikha OM, ElAlameeya IR, Elshafied AI, Sherifa LS et al. Serum vitamin D level as a predictor of bronchial asthma in egyptian children. J Arab Soc Med Res. 2013;8:67-75.

Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The Relationship between serum 25 hydroxy vitamin D levels and asthma in children. Allergy Asthma Immunol Res. 2011;3(4):251-5.

El-Menem MA, Al-Aziz MA, El-Guindy WM, El Banna NA. Frequency of vitamin d deficiency among asthmatic egyptian children. Egypt J Pediatr Allergy Immunol. 2013;11(2):69-73.

Menon B, Kaur C, Nema G. Evaluation of vitamin d in asthma and it’s correlation with lung function. ERJ. ERS. 2013;47:4700.

Poon AH, Mahboub B, Hamid Q. Vitamin D deficiency and severe asthma. Pharmacol Ther. 2013;140(2):148-55.

Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong. Int Arch Allergy Immunol. 2012;157(2):168-75.

Vasiliou JE, Lui S, Walker SA, Chohan V, Xystrakis E, Bush A et al. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airway disease. Allergy J. 2014;69(10):1380-9.