Assay of neonatal cord blood lipid levels and its correlation with neonatal gestational age, gender and birth weight: a single center experience

Authors

  • Yashaswini Kenchappa Department of Pediatrics, Sri Balaji Medical College and Hospital, Chrompet, Chennai, tamil nadu
  • Narendra Behera Department of Pediatrics, MKCG Medical College, Berhampur, Odisha

DOI:

https://doi.org/10.18203/2349-3291.ijcp20161905

Keywords:

Cord blood, Lipid profile, Hypercholesterolemia, Atherosclerosis, Barker’s hypothesis

Abstract

Background:It is a well-documented fact that atherosclerosis can originate in the fetal period itself. There is evidence that children with cholesterol levels in upper quartiles are at increased risk of subsequent atherosclerosis and numerous antenatal and perinatal factors may influence this atherogenesis. The current study tried to determine the levels of total cholesterol, triglycerides, LDL cholesterol, VLDL and HDL cholesterol in cord blood and correlate levels of these lipoproteins with various factors including fetal gender, gestational age, birth weight and gestational maturity and see whether these factors influence lipid profile in neonates.

Methods: Cord blood lipid profile including assessment of total cholesterol, triglycerides, LDL cholesterol, VLDL and HDL cholesterol was done involving 90 neonates.

Results:The low birth weight group and preterm neonates had higher and statistically significant levels of total cholesterol, triglycerides and LDL. They also had higher levels of HDL and VLDL, but the levels of these lipids were not statistically significant. No significant difference in lipid profile was noted based on gender and gestational maturity.

Conclusions:Our study results reaffirm the relation between cord blood lipid profile and perinatal factors. With the significantly unhealthy lipid profile among the preterm and low birth weight babies we might safely say that the preterm and low birth weight babies are exposed to a more hypercholesterolemic and potentially more atherogenic environment than their term counterparts and early lifestyle modifications may be required to prevent their progression to coronary artery disease.  

References

Rifai N, Bachorik PS, Albers JJ. Lipids, lipoproteins and apolipoproteins. In: Carl AB, Edward RA, editors. Teitz Textbook of Clinical Chemistry. 3rd edition. USA:WB Saunders;1999:826-830.

Barker DJP. The intrauterine origins of cardiovascular disease. Acta Paedia. 1993;391:93-9.

Goldstein JL, Albers JJ, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. Plasma lipid levels and coronary heart disease in adult relatives of new borns with normal and elevated cord blood lipids. Am J Hum Genet. 1974;26:727-35.

Gozlan O, Gross D, Gruener N. Lipoprotein levels in newborns and adolescents. Clin Biochem. 1994;27:305-6.

Lakhtakia JR, Dogra J, Mathur HC, Mishra SN. Serum lipid in neonatal cord blood in families with essential hypertension. Indian Pediatr. 1990;27:1101-3.

Low PS, Saha N, Tay JS, Hong S. Ethnic variation of cord plasma apolipoprotein levels in relation to coronary risk level: a study in three ethnic groups of Singapore. Acta Paediatr. 1996;85:1476-82.

Conathy WJ, Lane DM. Studies on the apolipoproteins and lipoproteins of cord serum. Pediatr Res. 1980;14:757-61.

Cloherty JP, Stark AR. Manual of neonatal care. 7th edition. Lippincott;2011:74-89.

Ballard JL, Khoury JC, Wedig K. New ballard score expanded to include extremely premature infants. J Pediatr. 1991;119:417.

Rajasekhar D, Saibaba KSS, Rao S, Latheef SAA, Subramanyam G. Lipoprotein: better assessor of coronary heart disease risk in South Indian population. Ind J Clin Biochem. 2004;19:53-9.

Barker DJP. Fetal origins of coronary artery disease. Br Med J. 1995;311:171-4.

Anderson GE, Hansen BF. Neonatal hypertryglyceridemia, a new index of ante partum and intrapartum fetal distress. Acta Pediatr Scand. 1976;65:369-73.

Tsang RC, Glueck CJ. Pediatric type hyperlipoproteinemia. Effect of diet on plasma cholesterol in the first year of life. Am J Clin Nutr. 1972;25:224-30.

Hardell L. Serum lipids and lipoproteins at birth based on a study of 2815 newborn infants. concentrations and distributions of triglycerides and cholesterol. Acta Pediatr Scand Suppl. 1981;285:5-10.

Zhao WH, Liu YJ, Shou HC, Chen LJ. Cholesterol concentrations in cord blood of newborn infants. Zhonghua Er Ke Za Zhi. 2003;2:107-9.

Kharb S, Kaur R, Singh V. Birth weight, cord blood lipoprotein and apolipoprotein levels in Indian newborns. International J Prev Med. 2010;1:23-4.

Badiee Z, Kelishadi R. Cord blood lipid profile in a population of Iranian term newborns. Pediatr cardiol. 2008;23(9):574-79.

Kumar A, Gupta A, Malhotra VK. Cord blood lipid levels in low birth weight newborns. Indian J Pediatrics. 1989;26:571-4.

Desai M, Patil K, Shah R, Mudholkar R. Cord blood lipids and lipoproteins in normal neonates. Indian paediatrics. 1977;14(5):373-7.

Mathur PP, Prasad R, Jain SK. Cord blood cholesterol in term and preterm newborns. Indian J Pedia. 1986;23:103-6.

Pushpendra M. Cord blood lipid profile at birth among normal Indian newborns and its relation to gestational maturity and birth weight. Indian J Res. 2013;2:215-7.

Mishra PK, Tiwari DK, Sharma B. Free fatty acids and triglycerides in normoglycemic low birth weight newborns. Indian J Pedia. 1984;51:637-41.

Haridas N, Acharya PT. Serum lipid status in neonates. Indian J Pediatrics. 1984;21:327-34.

Kalra A, Kalra K, Agarwal MC. Serum lipid profile in term and preterm infants. Indian J Pedia. 1988;25:977-81.

Jain R, Tripathi VN, Singh RD, Pandey K. Lipid profile and apolipoproteins in neonates in relation to birth weight and gestational maturity. J Pedia Sci. 2011;3(2):80.

Oba J, Doneya S, Raul C. Concentration of serum lipids and apo B in newborns. Arquiros Brasililerosde Cardiologica. 2006;2:86-90.

Christensen NC. Concentration of triglycerides, free fatty acids and glycerol in cord blood of new born infants. Acta Pediatr Scand. 1977;66:43-8.

Diaz M, Leal C, Cajal R. Cord blood lipoprotein-cholesterol: relationship to birth weight and gestational age of newborns. Metabolism. 1989;38:435-8.

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Published

2016-12-21

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Original Research Articles