Clinical profile and early outcomes of neonates born to mothers with thyroid dysfunction at a tertiary care center in North-East India

Priyanka Chettri; Chabungbam Smilie; Ngangom A. Singh; Chongtham S. Singh; Moirangthem R. Singh

doi:10.18203/2349-3291.ijcp20263310

Authors

Priyanka Chettri Department of Pediatrics, RIMS, Imphal, Manipur, India
Chabungbam Smilie Department of Pediatrics, RIMS, Imphal, Manipur, India
Ngangom A. Singh Department of Biochemistry, RIMS, Imphal, Manipur, India
Chongtham S. Singh Department of Pediatrics, RIMS, Imphal, Manipur, India
Moirangthem R. Singh Department of Obstetrics and Gynecology, RIMS, Imphal, Manipur, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20263310

Keywords:

Maternal thyroid dysfunction, Subclinical hypothyroidism, Neonatal outcomes, Congenital hypothyroidism, Newborn screening

Abstract

Background: The objectives of the study were to assess early neonatal outcomes among infants born to mothers with thyroid dysfunction and compare outcomes between subclinical and overt hypothyroidism.

Methods: This hospital-based cross-sectional study (May 2023-April 2025) included 72 neonates born to mothers with thyroid dysfunction. Comparative analysis was performed in neonates born to mothers with subclinical or overt hypothyroidism. Associations between neonatal morbidities and thyroid function were analysed using the Chi-square or Fisher’s exact test, with odds ratios and 95% confidence intervals.

Results: Subclinical hypothyroidism (SCH) was the most common maternal disorder (63.9%). Neonatal hyperbilirubinemia was the predominant morbidity (50%). Prematurity was significantly higher in the SCH group than in the overt hypothyroidism group (41.3% versus 16.7%, p=0.037). Other morbidities showed no significant differences. Congenital hypothyroidism (CH) was detected in 5.6% of neonates.

Conclusions: Subclinical maternal hypothyroidism is associated with prematurity, and the high prevalence of CH emphasizes the need for targeted neonatal thyroid screening.

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