Predictors of recurrence of febrile seizures: a prospective cohort study from a tertiary care centre
DOI:
https://doi.org/10.18203/2349-3291.ijcp20261532Keywords:
Anemia, Febrile seizure, Fever, Recurrent febrile seizure, Risk factors, SeizureAbstract
Background: This study was done to estimate various risk factors associated with the recurrence of febrile seizures in children aged 6 months to 5 years.
Methods: This prospective cohort study was conducted at Max Smart Super Speciality Hospital, New Delhi, on children aged 6 months to 5 years, admitted from June 2023 to May 2024. A total of 115 children presenting with their first episode of febrile seizures were enrolled and they were followed up for a period of 1 year. Children with CNS infections, afebrile seizures, or other exclusion criteria were omitted. History, clinical examination, and laboratory parameters including haemoglobin and serum sodium were recorded. Follow-up was conducted over one year. Data were analyzed using SPSS v24 with univariate analysis.
Results: Out of 115 children, 35 (30.4%) developed recurrent febrile seizures. Statistically significant associations were observed for age ≤1 year (p=0.008), prolonged seizure >5 minutes (p=0.0001), positive family history of FS (p=0.009), and haemoglobin <11 gm/dl (p=0.028). Gender, fever intensity, duration of fever, seizure type, and serum sodium levels were not significantly associated.
Conclusions: Younger age, prolonged seizures, positive family history, and anaemia were key predictors of FS recurrence. Early recognition of these factors can improve parental counselling and follow-up care strategies.
References
Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;121(6):1281-6.
Febrile seizures. J Child Neurol. 2002;17(Suppl 1):S44-52.
Foreman KJ, Marquez N, Dolgert A, Fukutaki K, Fullman N, McGaughey M, et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories. Lancet. 2018;392(10159):2052-90.
Devanand GC, Sakshi UB, Harsha V, Kumar R, Prashanth S. To study the risk factors for recurrence of febrile seizures in children in southern India. J Pharm Negat Results. 2022:14(1);87-92.
Kumar N, Midha T, Rao YK. Risk factors of recurrence of febrile seizures in children in a tertiary care hospital in Kanpur: a one year follow up study. Ann Indian Acad Neurol. 2019;22(1):31-6.
Agrawal J, Poudel P, Shah GS, Yadav S, Chaudhary S, Kafle S. Recurrence risk of febrile seizures in children. J Nepal Health Res Council. 2016;14(34):192-6.
Karimi P, Sayehmiri K, Azami M, Tardeh Z. The association between iron deficiency anemia and febrile seizure. Int J Adolesc Med Health. 2019;34(1).
Kazemi A, Badv RS, Fallah R, Piri A, Tahernia L, Vafaee Shahi M. The first febrile seizure; predisposing factors and recurrence rate. Iran J Child Neurol. 2021;15(2):69-76.
Canpolat M, Per H, Gumus H, Elmali F, Kumandas S. Investigating the prevalence of febrile convulsion in Kayseri, Turkey: an assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy. Seizure. 2018;55:36–47.
Indriani A, Risan NA, Nurhayati T. Five years study of recurrent febrile seizure risk factors. Althea Med J. 2017;4(2):281-6.
Habib Z, Akram S, Ibrahim S, Hasan B. Febrile seizures: factors affecting risk of recurrence in Pakistani children presenting at the Aga Khan University Hospital. J Pak Med Assoc. 2003;53(1):11-7.
Tosun A, Koturoglu G, Serdaroglu G, Polat M, Kurugol Z, Gokben S, et al. Ratios of nine risk factors in children with recurrent febrile seizures. Pediatr Neurol. 2010;43(3):177-82.
Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr. 2019 Sep 4;19(1):309.
Karimi P, Sayehmiri K, Azami M, Tardeh Z. The association between iron deficiency anemia and febrile seizure. Int J Adolesc Med Health.;34(1).
Berg AT, Shinnar S, Darefsky AS, Holford TR, Shapiro ED, Salomon ME, et al. Predictors of recurrent febrile seizures: a prospective cohort study. Arch Pediatr Adolesc Med. 1997;151(4):371-8.
Habib Z, Akram S, Ibrahim S, Hasan B. Febrile seizures: factors affecting risk of recurrence in Pakistani children presenting at the Aga Khan University Hospital. J Pak Med Assoc. 2003;53(1):11-7.
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