A cross-sectional survey on the usage, preference, and clinical experience of pediatricians with cefpodoxime in pediatric infections

Authors

  • Ajitkumar Gondane Medical Affairs Division, Alkem Laboratories, Mumbai, Maharashtra, India
  • Dattatray Pawar Medical Affairs Division, Alkem Laboratories, Mumbai, Maharashtra, India
  • Akhilesh Sharma Medical Division, Alkem Laboratories, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20260410

Keywords:

Physician perception, Treatment compliance, Palatability, Prescribing patterns

Abstract

Background: Cefpodoxime is frequently prescribed for pediatric bacterial infections; however, real-world insights into its usage patterns, preference, and clinical experience among pediatricians in India are limited. This study evaluated the prescribing trends, perceived efficacy, palatability, safety, and overall satisfaction with cefpodoxime in pediatric practice.

Methods: A cross-sectional survey was conducted among pediatricians attending the National Pedicon Conference 2026 using a structured questionnaire. Data on demographics, indications, comparative preference with other β-lactam antibiotics, clinical efficacy, palatability-associated compliance, safety, and satisfaction were collected from 300 respondents.

Results: Among 300 pediatricians, 69.7% were male and 31.0% female, with a mean age of 44.58±13.07 years. Cefpodoxime was most prescribed for lower respiratory tract infections (n=206), followed by pharyngitis/tonsillitis (n=186), acute otitis media (n=185), skin and soft tissue infections (n=67), and urinary tract infections (n=57). Across respiratory tract infections, cefpodoxime was consistently preferred over cefpodoxime–clavulanate and other β-lactam antibiotics. Clinical efficacy was rated as excellent by 199 respondents and good by 97, reflecting strong confidence in treatment outcomes. Palatability was reported to significantly improve pediatric patient compliance by 239 pediatricians, while 250 identified palatability as a key determinant of patient satisfaction. In terms of safety, 261 respondents reported no observed adverse events. Overall satisfaction was high, with 188 pediatricians being very satisfied and 107 satisfied with cefpodoxime use.

Conclusions: The survey highlights cefpodoxime as a preferred, effective, and well-tolerated antibiotic with added benefits of palatability-driven compliance in pediatric infections.

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References

Park K. Acute respiratory diseases. In: Park K, editor. Park’s textbook of preventive and social medicine. 26th edition. Jabalpur: Banarsidas Bhanot. 2021;183-9.

International Institute for Population Sciences (IIPS), ICF. National Family Health Survey (NFHS-5), 2019–2021. Mumbai: IIPS. 2021. Available at: http://rchiips.org/nfhs/NFHS-5. Accessed on 04 December 2026.

Turyasiima M, Kiconco G, Egesa WI, Twesigemukama S, Nduwimana M. Prevalence and outpatient clinical diagnostic approaches for common acute respiratory tract infections in children under five years of age: A Cross-Sectional study. Pediatr Health Med Ther. 2024;49-57. DOI: https://doi.org/10.2147/PHMT.S445908

Hong LT, Downes KJ, FakhriRavari A, Abdul-Mutakabbir JC, Kuti JL, Jorgensen S, et al. International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists. Pharmacotherapy. 2023;43(8):740-77. DOI: https://doi.org/10.1002/phar.2842

Fulton B, Perry CM. Cefpodoxime proxetil: a review of its use in the management of bacterial infections in paediatric patients. Paediatr Drugs. 2001;3(2):137-58. DOI: https://doi.org/10.2165/00128072-200103020-00006

Vallet T, Bensouda Y, Saito J, Mathiesen L, Pokharkar V, Klingmann V, et al. Exploring acceptability drivers of oral antibiotics in children: Findings from an international observational study. Pharmaceutics. 2021;13(10):1721. DOI: https://doi.org/10.3390/pharmaceutics13101721

Baguley D, Lim E, Bevan A, Pallet A, Faust SN. Prescribing for children–taste and palatability affect adherence to antibiotics: a review. Arc Dis Childhood. 2012;97(3):293-7. DOI: https://doi.org/10.1136/archdischild-2011-300909

Chocas EC, Paap CM, Godley PJ. Cefpodoxime proxetil: a new, broad-spectrum, oral cephalosporin. Ann Pharmacother. 1993;27(11):1369-77. DOI: https://doi.org/10.1177/106002809302701111

Indian Council of Medical Research (ICMR). Treatment guidelines for antimicrobial use in common syndromes: Dashboard. New Delhi: ICMR. 2022. Available at: https://amrtg.icmr.org.in /dashboard.html. Accessed on 04 December 2025.

National Centre for Disease Control (NCDC). National Treatment Guidelines for Antimicrobial Use in Infectious Diseases. Version 1.0. Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India. 2016. Available at: https://ncdc.mohfw.gov.in/wp-content/ uploads/2024/03/16436207411618303414.pdf. Accessed on 04 December 2025.

Jain A, Thacker H, Singh J, Manya S, Gautam A, Padalia H. A Study of Expert Perspectives on the Administration of Cefpodoxime and its Combinations in Respiratory Infections: PERCEPT Survey. J Assoc Physicians of India. 2025;73(7):72-8. DOI: https://doi.org/10.59556/japi.73.1054

Manjula S, Krishna Kumar M. Expert opinion on the prescription practice of cefpodoxime in the management of respiratory tract infections in Indian settings. J Adv Med Med Res. 2024;36(6):42-9. DOI: https://doi.org/10.9734/jammr/2024/v36i65449

Manjula S, Krishna Kumar M. Clinicians perspectives on cefpodoxime in acute otitis media. Int J Otolaryngol Res. 2024;6(1):01-5. DOI: https://doi.org/10.33545/26646455.2024.v6.i1a.33

Michelow IC, McCracken GH. Antibacterial therapeutic agents, Editor(s): Feigin RD, Cherry JD, Demmler-Harrison GJ, Kaplan SL. Feigin and Cherry's Textbook of Pediatric Infectious Diseases (Sixth Edition), W.B. Saunders. 2009;3178-227. DOI: https://doi.org/10.1016/B978-1-4160-4044-6.50253-3

Elgammal A, Ryan J, Bradley C, Crean A, Bermingham M. The impact of drug palatability on prescribing and dispensing of antibiotic formulations for paediatric patients: a cross-sectional survey of general practitioners and pharmacists. Family Pract. 2024;41(6):962-9. DOI: https://doi.org/10.1093/fampra/cmad071

Bradshaw H, Mitchell MJ, Edwards CJ, Stolz U, Naser O, Peck A, et al. Medication palatability affects physician prescribing preferences for common pediatric conditions. Acad Emerg Med. 2016;23(11):1243-7. DOI: https://doi.org/10.1111/acem.13020

Janarthanan R, Pal A, Pawar D, Sharma A. Physicians’ perspectives and opinion towards the utilization of cefpodoxime proxetil: a nationwide study. Int J Toxicol Pharmacol Res. 2024;14(11):250-6.

Hamid OA, Dokhan MA, El Gamea A, Ahmed HA, Feseekh NT, El Deghedy MA, et al. Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry. Egypt J Ear Nose Throat Allied Sci. 2017;18(2):131-5. DOI: https://doi.org/10.1016/j.ejenta.2017.08.002

El-Shabrawi MH, Tolba OA, El-Adly TZ. Efficacy and safety of cefpodoxime in the treatment of acute otitis media in children. Egypt Pediatr Assoc Gazette. 2016;64(2):81-5. DOI: https://doi.org/10.1016/j.epag.2016.03.001

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Published

2026-02-21

How to Cite

Gondane, A., Pawar, D., & Sharma, A. (2026). A cross-sectional survey on the usage, preference, and clinical experience of pediatricians with cefpodoxime in pediatric infections. International Journal of Contemporary Pediatrics, 13(3), 473–479. https://doi.org/10.18203/2349-3291.ijcp20260410

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Original Research Articles