Impact of organoleptic properties on pediatric antibiotic compliance: a comparative study of three commonly prescribed co-amoxyclav suspensions in India
DOI:
https://doi.org/10.18203/2349-3291.ijcp20254176Keywords:
Antibiotic compliance, Co-amoxyclav, Organoleptic properties, Pediatric adherence, Taste evaluationAbstract
Background: Palatability is a crucial factor influencing adherence of medication in pediatric populations, especially for oral antibiotic suspensions. This study aimed to evaluate and compare the organoleptic properties of three co-amoxyclav 457 mg formulations: Product A (Advent), Product B (Comparator 1) and Product C (Comparator 2) in 55 healthy school-going children aged 6 to 9 years.
Methods: Each product was administered at 15–20-minute intervals and responses were recorded using a structured questionnaire that included behavioural analysis, taste discrimination, ranking and compliance perception.
Results: Product A showed the highest acceptability, with 94.5% of children displaying favourable facial expressions and 100% accepting the product. Based on taste, 91% rated product A as excellent or good, compared to 67% for product B and 82% for product C. Additionally, 85% of participants described product A’s taste as sweet, with a fruity orange aftertaste. Smell ratings were also highest for Product A, with 89% rating it excellent or good, versus 71% for product B and 73% for product C. Regarding aftertaste, 78% found product A sweet, while about 55% found products B and C sweet. Overall, 57% of children preferred product A and more than 90% assured they would complete the course if prescribed this formulation.
Conclusions: These findings highlight the importance of organoleptic properties in pediatric antibiotic formulations. By considering organoleptic properties during prescribing, healthcare providers can significantly enhance adherence, leading to improved treatment outcomes and a reduced risk of antimicrobial resistance.
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References
Adapted from CAHMI. Data Resource Center for Child and Adolescent Health. 2016. Avaualble at: https://www.childhealthdata.org. Accessed on 16 August 2025.
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