Estimation of serum vitamin D level in childhood asthma at a tertiary care hospital in Bangladesh

S. M. Zakaria Hossain; Shohela Akhter; Taskina Mosleh

doi:10.18203/2349-3291.ijcp20253773

Authors

S. M. Zakaria Hossain 1Department of Paediatric, 100 Bedded Zila Hospital, Narsingdi, Bangladesh; Department of Paediatrics, Bangladesh Medical University, Dhaka, Bangladesh https://orcid.org/0000-0003-0015-2226
Shohela Akhter Department of Paediatrics, Bangladesh Medical University, Dhaka, Bangladesh
Taskina Mosleh Department of Paediatrics, Bangladesh Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2349-3291.ijcp20253773

Keywords:

Asthma, Children, 25 hydroxy vitamin D

Abstract

Background: Asthma is a prevalent chronic disease that significantly affects children globally, with implications for both health and quality of life. Recently, vitamin D deficiency has been associated with various respiratory disorders, including asthma. However, the relationship between vitamin D levels and asthma severity remains unclear, particularly in Bangladeshi children. This study aims to evaluate and compare serum 25-hydroxyvitamin D levels between children with asthma and healthy controls, examining whether vitamin D insufficiency is associated with different asthma subtypes.

Methods: A cross-sectional study was conducted at the paediatrics department of Bangladesh medical university (BMU), Dhaka, Bangladesh, from October 2020 to October 2021. A total of 90 children aged 8-18 years were enrolled: 60 children with asthma and 30 healthy controls. Serum 25-hydroxyvitamin D levels were measured and compared between the two groups. Additionally, the relationship between vitamin D levels and asthma subtypes was analysed.

Results: The mean serum vitamin D level in asthmatic children was significantly lower (24.7±7.1 ng/ml) compared to non-asthmatic children (35.9±7.6 ng/ml, p<0.001). Vitamin D deficiency was present in 23.3% of asthmatic children compared to 13.3% in the control group. However, no significant correlation was found between vitamin D levels and asthma severity.

Conclusions: Children with asthma exhibited significantly lower serum vitamin D levels than their healthy counterparts. While this study highlights the association of vitamin D deficiency with asthma, further research is needed to clarify its role in asthma severity.

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Author Biography

S. M. Zakaria Hossain, 1Department of Paediatric, 100 Bedded Zila Hospital, Narsingdi, Bangladesh; Department of Paediatrics, Bangladesh Medical University, Dhaka, Bangladesh

Medical officer,

100bed Narsingdi Zila Hospital, Bangladesh

Ex- Resident,

Dept. of Paediatrics,

Bangabandhu Sheikh Mujib Medical University (BSMMU),

Shahbag, Dhaka.

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