Salmonella typhimurium sepsis in a neonate: a rare and challenging case

Authors

  • Larissa R. Dabre Ankur Pediatric Multispeciality Hospital, Mumbai, Maharashtra, India
  • Samir Sheikh IONA Newborn Hospital, Mumbai, Maharashtra, India
  • Vaibhavi S. Barot Ankur Pediatric Multispeciality Hospital, Mumbai, Maharashtra, India
  • Dhruvi Amrutiya Ankur Pediatric Multispeciality Hospital, Mumbai, Maharashtra, India
  • Shailesh Barot Ankur Pediatric Multispeciality Hospital, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20253496

Keywords:

Neonatal sepsis, Salmonella typhimurium, Rare infection, Blood culture, Antibiotics

Abstract

Neonatal sepsis attributed to Salmonella infection is a relatively rare phenomenon. It can have varied presentation encompassing mild, subclinical presentations to severe life-threatening complications and death. Prompt administration of appropriate antibiotics forms cornerstone of treatment. Authors present a case of 25-day-old neonate, who presented with fever, lethargy, respiratory distress, and signs of dehydration. Upon evaluation, the neonate was diagnosed with sepsis caused by Salmonella enterica serovar typhimurium. Prompt medical management was initiated, and the neonate responded well to treatment. The patient made a full recovery without any residual comorbidities or complications.

Metrics

Metrics Loading ...

References

Chaurasia S, Jeeva Sankar M, Agarwal R, Yadav CP, Arya S, Kapil A, et al. Characterisation and antimicrobial resistance of sepsis pathogens in neonates born in tertiary care centres in Delhi, India: a cohort study. Lancet. 2016;4(10):752-60. DOI: https://doi.org/10.1016/S2214-109X(16)30148-6

Yen Y, Wang F, Chiou C, Chen Y, Lin M, Chen T. Prognostic factors and clinical features of non-typhoid Salmonella bacteraemia in adults. J Chin Med Assoc. 2009;72(8):408-13. DOI: https://doi.org/10.1016/S1726-4901(09)70397-1

Jain S, Bhakoo O. Salmonella infection in the newborn. A review with special reference to nursery epidemics. Indian Pediatr. 1979;16(7):629-35.

Reed RP, Klugman KP. Neonatal typhoid fever. Pediatr Infect Dis J. 1994;13(9):774–6. DOI: https://doi.org/10.1097/00006454-199409000-00004

Fàbrega A, Vila J. Salmonella entericaserovar Typhimurium virulence and regulation. ClinMicrobiol Rev. 2013;26(2):308–41. DOI: https://doi.org/10.1128/CMR.00066-12

Raveendran R, Wattal C, Sharma A. Vertical transmission of Salmonella Paratyphi A: rare neonatal enteric fever. Indian J Pediatr. 2007;74(8):784–6. DOI: https://doi.org/10.1007/s12098-007-0141-8

Ojukwu JU, Abonyi LE, Ugwu J, Orji IK. Neonatal Salmonella infection: clinical features and outcome. Ann Trop Paediatr. 1996;16(4):345–9.

Sharan R, Kumar S. Salmonella infection in newborn-varied presentation from sepsis to shock. J Clin Neonatol. 2013;2(3):153. DOI: https://doi.org/10.4103/2249-4847.120015

Tran Minh NN. Salmonella meningitis in neonates: case report and review. J Trop Pediatr. 2005;51(2):114–8.

Gupta A. Neonatal brain abscesses due to Salmonella. Indian J Pediatr. 1993;60(1):139–41. DOI: https://doi.org/10.1007/BF02860497

Gupta S. Neonatal cholecystitis caused by Salmonella. J Pediatr Surg. 1991;26(5):565–7.

Mohanty S, Gaind R, Sehgal R, Chellani H, Deb M. Neonatal sepsis due to Salmonella Typhi and Paratyphi A: case series. J Infect Dev Ctries. 2009;3(8):633–8. DOI: https://doi.org/10.3855/jidc.557

Wing E, Trepoli G. Vertical transmission of typhoid fever: an early description. Arch Dis Child. 1930;2:56.

Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella Typhimurium DT 104. Lancet. 1997;349(9060):1056–7.

Kariuki S, Gordon MA, Feasey N, Parry CM. Antimicrobial resistance and management of invasive Salmonella disease. Vaccine. 2015;33:21–9. DOI: https://doi.org/10.1016/j.vaccine.2015.03.102

Feasey NA. Invasive Salmonella in Africa: epidemiology, burden, and resistance. Lancet Infect Dis. 2012;12(6):434–43.

Bhan MK. Neonatal septicemia due to resistant Salmonella: carbapenem therapy. J Trop Pediatr. 2000;46(2):123–5.

Subhash K, Jitendranath A, Ramani Bai JT, Luke MS. Rare case of neonatal sepsis due to Salmonella Typhimurium. IP Int J Med Microbiol Trop Dis. 2025;8(3):267–9. DOI: https://doi.org/10.18231/j.ijmmtd.2022.052

Downloads

Published

2025-10-28

How to Cite

Dabre, L. R., Sheikh, S., Barot, V. S., Amrutiya, D., & Barot, S. (2025). Salmonella typhimurium sepsis in a neonate: a rare and challenging case. International Journal of Contemporary Pediatrics, 12(11), 1878–1881. https://doi.org/10.18203/2349-3291.ijcp20253496

Issue

Section

Case Reports