Clinico-pathological profile of bronchiolitis in Dhaka Medical College Hospital, Bangladesh
DOI:
https://doi.org/10.18203/2349-3291.ijcp20253476Keywords:
Bronchiolitis, Respiratory syncytial virus, WheezingAbstract
Background: Bronchiolitis is a lower respiratory tract infection characterized by obstruction of small airways caused by acute inflammation, edema and necrosis of the epithelial cells. It is mostly present in infants aged three to six months. The most common etiology is the respiratory syncytial virus (RSV) with the highest incidence of RSV infection occurring between December and March. This study was undertaken to assess clinico-pathological profile of children affected by bronchiolitis.
Methods: This descriptive cross-sectional observation study was conducted at department of paediatrics, Dhaka medical college and hospital (DMCH), Dhaka, Bangladesh between January to December of 2013. To find out the clinico-epidemiological and radiological profile of bronchiolitis. Children below 24 months of age diagnosed as bronchiolitis were studied.
Results: 100 children were evaluated, including 73 boys and 27 girls; Infants below 6 months accounted for the highest proportion (64%). All the bronchiolitis patients had runny nose, cough or cold with respiratory distress. Other symptoms were feeding difficulty (56.0%) and fever (46.0%). On examination lower chest in drawing and rhonchi were found in all cases. Increased translucency (82%) and hyperinflation (77%) was the most prevalent radiological findings.
Conclusions: Most children present with typical clinical and radiological feature of bronchiolitis which can help the clinicians to clinically identify this disease more efficiently.
Metrics
References
Nagakumar P, Doull I. Current therapy for bronchiolitis. Arch Dis Child. 2012;97(9):827-30. DOI: https://doi.org/10.1136/archdischild-2011-301579
Zorc JJ, Hall CB. Bronchiolitis: recent evidence on diagnosis and management. Pediatrics. 2010;125(2):342-9. DOI: https://doi.org/10.1542/peds.2009-2092
Wainwright C. Acute viral bronchiolitis in children- a very common condition with few therapeutic options. Paediatr Respir Rev. 2010;11(1):39-45. DOI: https://doi.org/10.1016/j.prrv.2009.10.001
Ray CG, Minnich LL, Holberg CJ, Shehad ZM, Wright AL, Barton LL, et al. Respiratory syncytial virus-associated lower respiratory illnesses: possible influence of other agents. Pediatr Infect Dis. 1993;12(1):15-9. DOI: https://doi.org/10.1097/00006454-199301000-00005
Fitzgerald DA, Kilham HA. Bronchiolitis: assessment and evidence-based management. Med J Aust. 2004;180(8):399-404. DOI: https://doi.org/10.5694/j.1326-5377.2004.tb05993.x
Consensus Statement on Guidelines for the Management of Bronchiolitis. Workshop on formulation of the management guidelines on bronchiolitis for field level health care providers. EPIHQ, DGHS. 2004.
Kuzik BA. Maybe there is no such thing as bronchiolitis. CMAJ. 2016;188(5):351-4. DOI: https://doi.org/10.1503/cmaj.150683
Øymar K, Skjerven HO, Mikalsen IB. Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med. 2014;22:23. DOI: https://doi.org/10.1186/1757-7241-22-23
Lakhanpaul M, MacFaul R, Werneke U, Armon K, Hemingway P, Stephenson T. An evidence-based guideline for children presenting with acute breathing difficulty. Emerg Med J. 2009;26(12):850-3. DOI: https://doi.org/10.1136/emj.2008.064279
Kabir ML, Haq N, Hoque M, Ahmed F, Amin R, Hossain A, et al. Evaluation of hospitalized infants and young children with bronchiolitis-a multi centre study. Mymensingh Med J. 2003;12(2):128-33.
Welliver TP, Reed JL, Welliver RC Sr. Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases. Pediatr Infect Dis J. 2008;27(10):S92-6. DOI: https://doi.org/10.1097/INF.0b013e318168b706
Spence L, Barratt N. Respiratory syncytial virus associated with acute respiratory infections in Trinidadian patients. Am J Epidemiol. 1968;88(2):257-66. DOI: https://doi.org/10.1093/oxfordjournals.aje.a120884
Yanney M, Vyas H. The treatment of bronchiolitis. Arch Dis Child. 2008;93:793-8. DOI: https://doi.org/10.1136/adc.2007.128736
Henderson FW, Clyde WA Jr, Collier AM, Denny FW, Senior RJ, Sheaffer CI, et al. The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J Pediatr. 1979;95(2):183-90. DOI: https://doi.org/10.1016/S0022-3476(79)80647-2
Glezen P, Denny FW. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973;288(10):498-505. DOI: https://doi.org/10.1056/NEJM197303082881005
Simoes EA. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease. J Pediatr. 2003;143(5):S118-26. DOI: https://doi.org/10.1067/S0022-3476(03)00511-0
Schroeder AR, Mansbach JM. Recent evidence on the management of bronchiolitis. Curr Opin Pediatr. 2014;26(3):328-33. DOI: https://doi.org/10.1097/MOP.0000000000000090
Singh C, Angurana SK, Bora I, Jain N, Kaur K, Sarkar S. Clinicodemographic profiling of the Respiratory syncytial virus (RSV) infected children admitted in tertiary care hospital in North India. J Family Med Prim Care. 2021;10(5):1975-80. DOI: https://doi.org/10.4103/jfmpc.jfmpc_2406_20
Nguyen SN, Nguyen TNT, Vu LT, Nguyen TD. Clinical Epidemiological Characteristics and Risk Factors for Severe Bronchiolitis Caused by Respiratory Syncytial Virus in Vietnamese Children. Int J Pediatr. 2021;2021:9704666. DOI: https://doi.org/10.1155/2021/9704666
Soleimani G, Shafighi Shahri E, Rashidi S, Salari Z, Ansari Moghadam A. Epidemiology, Clinical, and Laboratory Characteristics of Bronchiolitis in Hospitalized Children. J Compr Ped. 2014;5(3):e18808. DOI: https://doi.org/10.17795/compreped-18808
Ahmed F, Kabir ARML, Haq N. Radiological Evaluation of 162 Cases of Bronchiolitis Bangladesh J Child Health. 2003;27(1):6-9.