Study of seizures among pediatric age group (0-12 years) in tertiary health care center of a district of Maharashtra, India
DOI:
https://doi.org/10.18203/2349-3291.ijcp20170700Keywords:
Convulsions, Neonatal seizures, SeizuresAbstract
Background: Seizures represent the most distinctive signal of neurological disease in the newborn period and these convulsive phenomena are the most frequent of the overt manifestation of neonatal neurological disorders. Recognition and classification of seizures remain problematic; particularly when pediatricians rely only on clinical criteria. The objective of this study was to study the incidence of pediatrics (0-12 years) seizures. To study the etiology and pattern of seizures.
Methods: 326 Subjects who had seizures were included in the study. Relevant history was ascertained from a patient’s parents or a reliable relative or attendant, medical records and the referring physicians note, specifically from mother in case of neonatal seizures i.e. age at onset of seizures, seizure activity with special emphasis on occurrence of 1st seizures, duration of seizures, number and type of seizures, associated autonomic changes, medications required to control seizures, response time to medications, and possible causes for determination of etiology. A detailed antenatal, natal and postnatal history was taken.
Results: Out of 326 study subjects 117 (35.89%) were in neonatal age group, of which 75 (64.10%) and 42 (35.90%) were male and female respectively and 209 (64.11%) were beyond neonatal age, out of which 125 (59.8%) were male and 84 (40.2%) female. out of 117 neonatal seizures, 75 (64.10%) neonates were male and 42 (35.90%) were female. Male: Female ratio was 1.79:1. The seizures were common in male neonates. Subtle seizures were the commonest type of seizures observed both in term and preterm neonates.
Conclusions: The various types of seizure were compared with the preterm and term neonates and it was found statistically significant (X2 = 5.06 d.f. = 4, p<0.05). The various causes of seizure were compared with the preterm and term neonates and it was found statistically significant (X2= 17.42 d.f. = 6 p<0.05).
References
Volpe JJ. Neonatal Seizures. In: Volpe JJ. Neurology of the newborn 4th edi. Philadelphia: W.B. Saunders; 2001:178-216.
Scher MS. Controversies regarding the neonatal Seizures recognition and epileptic disorders. J Neonat. 2002;4(2):139-58.
Eli M. Neonatal Seizures and neonatal epileptic syndromes. Neurol Clin Epilep. 2001;19(2):427-56.
David P, De Vivo DC. The nervous system. In: Rudolph Colin D. Abraham D. Rudolph, Margaret K. Hostellter, 21st edi. New York: McGraw Hills; 2002:2267.
Hauser WA. The prevalence and incidence of convulsion disorders in children. Epilepsia. 1994;35(Suppl. S1-6).
Offringa M, Moyer VA. Evidence based management of seizures associated with fever. BMJ 2001;323:111-14.
Johnston MV. Seizures in childhood. Kliegman, Behrman, Jenson, Stanton. Nelson text book of paediatrics; 18th edition. Elsevier Philadelphia Sanders; 2008:2457.
Senanayake N, Roman G. Epidemiology of epilepsy in the trophics. Trop Geogr Neurol. 1992;2:610-9.
Sandhu R, Thakur P, Kesavamurthy SR. A clinical study of Seizures in Neonate. In: Manual abstracts of Pedicon. National conference of Indian Academy of Pediatrics. Mumbai: IAP 2003;Neo/52:203-4.
Grover N. Biochemical abnormalities in neonatal seizures. In: Manual abstracts of Pedicon. National conference of Indian Academy of Paediatrics. Mumbai: IAP. 2003;Neo/10:175.
Kumar A, Gupta A, Thakur NK. Clinical profile of Neonatal Seizures and there co-relation with EEG in a referral neonatal unit. In: Manual abstracts of XXIII Annual convention of National neonatology Forum. 2003;32:90-1.
Errikscon M, Zelterstrom R. Neonatal convulsion, incidence and causes in stockholm area. Acta Pediatric Scand. 1979;68:807-11.
Taksande AM, Vilhekar K, Jain M, Lakra M. Clinico-biochemical profile of neonatal seizures. Indian journal of pediatrics.1995;52:424-7.
Faiz N, Malik M, Azam M, Afzal U. Etiology and types of neonatal seizures. Ann Pak Inst Med. Sci. 2009;5(2):77-80.
Holden KR, Mellitus ED, Freemann JM. Neonatal seizures: correlation of prenatal and perinatal events with outcome. Pediatr. 1982;70(2):165-76.
Powell C, Painter MJ, Pipeger CE. Primidone therapy in refractory seizures. J Pediatr. 1983;105:651-4.
Scher MS, Aso K, Beggarly ME. Electrographic Seizures in preterm and fullterm neonate: clinical correlate, associated brain lesions and risk factor neurological sequalae. Paediatr. 1993;91(1):128-34.
Legido A, Clancy RR, Berman PH. Neurologic outcome after electroencephalographically proven neonatal seizures. Pediatr. 1991;88(3):583-96.
Kumar A, Gupta V, Singla K. A study of biochemical abnormalities in neonatal seizures. Indian J Pediatr. 1995;52:424-7.
Volpe JJ. Neonatal seizures. In: Volpe JJ. Neurology of the Newborn, 3rd edi. New York: W.B. Saunders; 2004:172 -207.
Reynolds EH. Epilepsy in the world. Launch of the Second Phase of the ILAE/IBE/Who Global Campaign Against Epilepsy. Epilepsia. 2002;43(suppl. 6):1-3.
