Clinical profile and predictors of immediate outcome in children with status epilepticus

Authors

  • Nitish Kumar P. Nandini Department of Pediatrics, Father Muller Medical College Hospital, Mangalore, Karnataka, India
  • K. Varadaraj Shenoy Department of Pediatrics, Father Muller Medical College Hospital, Mangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20251862

Keywords:

Status epilepticus, Clinical profile, Predictors

Abstract

Background: Aim of the study was to study the clinical profile, and predictors of immediate outcome in children aged 1 month to 15 years, with status epilepticus admitted to tertiary care center.

Methods: A prospective study of 43 patients admitted in department of pediatrics in Father Muller medical college between October 2017 to April 2019. They were evaluated for their clinical presentation, treatment profile and immediate outcome.

Results: Twenty-one children (49%) were between 1 to 5 years, seven children (16%) were below 1 year and fifteen (35%) were between 5 to 15 years. Thirty children (70%) were male and thirteen (30%) were female. Twenty-six patients (60.4%) had unprovoked status epilepticus. Twelve children (28%) had pre-existing neurological abnormality. Three patients died (6%) during hospital course and six patients (13.9%) had new onset neurological deficits and rest recovered.

Conclusions: Unprovoked seizures, presence of pre-existing neurological abnormalities, significant birth history, metabolic abnormalities and need for ventilation was associated with new onset neurological deficit and mortality. Overall children with preexisting neurological abnormality presenting with status epilepticus have poorer outcome.

Metrics

Metrics Loading ...

References

Gulati S, Kalra V and Sridhar M. Status epilepticus in Indian children in a tertiary care center. Indian J Pediatr. 2005;72(9):789-91. DOI: https://doi.org/10.1007/BF02734153

Lowenstein D, Bleck T, Macdonald R. It's Time to Revise the Definition of Status Epilepticus. Epilepsia. 1999;40(1):120-2. DOI: https://doi.org/10.1111/j.1528-1157.1999.tb02000.x

Chin R, Neville B, Peckham C, Bedford H, Wade A, Scott R. Incidence, cause, And short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. The Lancet. 2006:368(9531):222-9. DOI: https://doi.org/10.1016/S0140-6736(06)69043-0

Santhanam I, Yoganathan S, Sivakumar VA, Ramakrishnamurugan R, Sathish S, Thandavarayan M. Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: A retrospective observational study. Ann Indian Acad Neurol. 2017;20(2):142-8 DOI: https://doi.org/10.4103/aian.AIAN_369_16

Nishiyama I, Ohtsuka Y, Tsuda T, Kobayashi K, Inoue H, Narahara K, et al. An epidemiological study of children with status epilepticus in Okayama, Japan: Incidence, etiologies, and outcomes. Epilepsy Res. 2011;96(1-2):89-95. DOI: https://doi.org/10.1016/j.eplepsyres.2011.05.004

Shinnar S, Pellock J, Berg A, O'Dell C, Driscoll S, Maytal J, et al. Short-Term Outcomes of Children with Febrile Status Epilepticus. Epilepsia. 2008;42(1):47-53. DOI: https://doi.org/10.1046/j.1528-1157.2001.10000.x

Selvan T, V. N, P. S, Tudu M. A study of the aetiology and short-term outcome of status epilepticus in children. Int J Contemporary Pediatr. 2017;4(3):878. DOI: https://doi.org/10.18203/2349-3291.ijcp20171690

DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, Penberthy L, et al. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology. 1996;46(4):1029-35. DOI: https://doi.org/10.1212/WNL.46.4.1029

Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hauser WA. Incidence of status epilepticus in Rochester, Minnesota. 1965-1984. Neurology. 1998;50(3):735-41. DOI: https://doi.org/10.1212/WNL.50.3.735

Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366(7):591 600. DOI: https://doi.org/10.1056/NEJMoa1107494

Longroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Short term mortality after a first episode of status epilepticus. Epilepsia. 1997;38(12):1344-9. DOI: https://doi.org/10.1111/j.1528-1157.1997.tb00073.x

Downloads

Published

2025-06-25

How to Cite

P. Nandini, N. K., & Shenoy, K. V. (2025). Clinical profile and predictors of immediate outcome in children with status epilepticus. International Journal of Contemporary Pediatrics, 12(7), 1115–1119. https://doi.org/10.18203/2349-3291.ijcp20251862

Issue

Section

Original Research Articles