Hypothyroidism as an unusual emerging initial clinical manifestation in systemic lupus erythematosus
DOI:
https://doi.org/10.18203/2349-3291.ijcp20251488Keywords:
Hypothyroidism, Systemic lupus erythematosus, Autoimmune diseaseAbstract
Systemic lupus erythematosus (SLE) is a multisystem autoimmune inflammatory disorder which may be associated with other auto immune disorders. studies found that thyroid abnormalities were common in SLE patients. Here we are reporting a case of an adolescent girl initially presented with features of hypothyroidism who was later presented with anorexia, joints pain, pain abdomen with malar rash and discoid rash and diagnosed as systemic lupus erythematosus. emphasizing the importance of recognizing overlapping autoimmune disorders in pediatric patients, and the importance of thyroid disease should be acknowledged in the treatment of SLE.
Metrics
References
Chaudhary SN, Rahman SA, Islam MI. Thyroid Functions and Thyroid Auto-Antibodies in pediatric Systemic Lupus Erythematosus patients. A Study from Bangladesh. Am J Clin Exp Med. 2015;3(5):207-12. DOI: https://doi.org/10.11648/j.ajcem.20150305.12
Hiraki LT, Benseler SM, Tyrrel PN, Hebert D, Harvey E, Silverman ED. Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus; a longitudinal study. J Pediatr. 2008;152:550-6. DOI: https://doi.org/10.1016/j.jpeds.2007.09.019
Zhang X, Xu B, Liu Z, Gao Y, Wang Q, Liu R. Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: a case report. Exp Ther Med. 2020;20:996-1002. DOI: https://doi.org/10.3892/etm.2020.8788
Watad A, Mahroum N, Whitby A, Gertel S, Comaneshter D, Cohen AD, et al. Hypothyroidism among SLE patients: case control study. Autoimmune Rev. 2016;15:484-6. DOI: https://doi.org/10.1016/j.autrev.2016.01.019
Engler H, Staub JJ, Althaus B, Ryff-de Leche A, Gerber H. Assessment of antithyroglobulin and antimicrobial at antibodies in patients with autoimmune thyroid disease; comparison of hemagglutination assay, enzyme linked immunoassay and radioligand assay. Clin Chim Acta. 1989;179(3):251-63. DOI: https://doi.org/10.1016/0009-8981(89)90087-9
Smith EMD, Lythgoe H, Midgley A, Beresford MW, Hedrich CM. Juvenile-onset systemic lupus erythematosus: Update on clinical presentation, pathophysiology and treatment options. Clin Immunol. 2019;108274. DOI: https://doi.org/10.1016/j.clim.2019.108274
Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. 2019 European League Against Rheumatism /American College of Rheumatology Classification criteria for Systemic Lupus Erythematosus. Arthritis Rhematol. 2019;71(9):1400-12. DOI: https://doi.org/10.1002/art.40930
Domingues SL, Goncalves FT, Joege ML, Limongi JE, Ranza R, Jorge PT. High prevalence of hypothyroidism in the systemic lupus erythematosus patients without an increase in circulating anti-thyroid antibodies. Endocr Pract. 2017;23:1304-10. DOI: https://doi.org/10.4158/EP161664.OR
Dong L, Jia L, Hong X, Chen G, Mo H. Subclinical hypothyroidism is a risk factor for delayed clinical complete response in patients with systemic lupus erythematosus. Int J Clin Exp Med. 2014;7:2836-43.
Alves C, Robazzi TC, Fragomani M. Diagnosis of juvenile systemic lupus erythematosus in adolescents with Hashimoto’s thyroiditis: two case reports. Acta Rheumatol Port. 2010;35(3):362-5.