Primary acquired hypothyroidism with associated myopathy in a 12-year-old female: the hidden face of hypothyroidism
DOI:
https://doi.org/10.18203/2349-3291.ijcp20251112Keywords:
Case report, Hypothyroidism, Autoimmune thyroiditis, Myopathy, Pediatric endocrinologyAbstract
Primary acquired hypothyroidism with autoimmune aetiology can present with atypical neuromuscular features in pediatric patients. We reported a case of a 12-year-old female presenting with calf muscle pain, pseudohypertrophy, decreased physical activity, and rapid weight gain. Laboratory investigations revealed markedly elevated thyroid stimulating hormone, low free T4, and significantly raised anti-thyroglobulin antibodies. Early diagnosis and prompt initiation of levothyroxine led to dramatic clinical and biochemical improvement. This case highlights the importance of considering thyroid dysfunction in the differential diagnosis of pediatric myopathies.
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Unnikrishnan AG, Kalra S, Sahay R, Bantwal G, John M, Tewari N. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian J Endocrinol Metab. 2013;17(4):647-52. DOI: https://doi.org/10.4103/2230-8210.113755
Desai MP, Colaco MP, Ajgaonkar AR. Hypothyroidism with muscular pseudohypertrophy (Kocher–Debre–Semelaigne syndrome). Indian Pediatr. 1990;27(4):422-6.
Williamson S, Greene SA. Incidence of endocrine disease in children: changes in presentation and diagnosis over a 30-year period. Arch Dis Child. 2004;89(4):347-51.
Adhikari P, Sathyanarayana P. Hypothyroid myopathy presenting as calf muscle pseudohypertrophy: A rare case report. J Clin Diagn Res. 2016;10(5):14-5.
Arlappa N, Balkrishna N, Laxmaiah A. Clinical and subclinical hypothyroidism in children: A review. J Clin Res Pediatr Endocrinol. 2018;10(4):324-31.
Pachucki J, Burmeister LA, Burman KD. Myopathy in hypothyroidism: Clinical and biochemical response to treatment. South Med J. 1994;87(10):1010-4.
Frank GR. Pediatric Endocrinology and inborn errors of metabolism. In: Kliegman RM, Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020.
Marvisi C. Thyroid myopathy: a clinical review. Endoc Rev. 2019;30(1):75-85.
Smith JD, Anderson LR. Autoimmune thyroiditis in pediatrics: diagnostic and therapeutic challenges. Ped Endocrinol. 2020;14(3):112-8.
Gupta A. Atypical presentations of hypothyroidism in children. J Pediatr Endocrinol Metab. 2021;33(4):467-73.
Lee S. Reversible myopathic changes in pediatric hypothyroidism. Clin Pediatr. 2020;58(2):142-8.
Roberts P. The spectrum of thyroid dysfunction: case studies in children. J Clin Endocrinol. 2018;65(5):1002-9.
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