Malaria parasitaemia among the neonates in Akure Ondo State, Nigeria
DOI:
https://doi.org/10.18203/2349-3291.ijcp20251462Keywords:
Neonates, Malaria, Parasitaemia, Akure, Ondo stateAbstract
Background: Congenital malaria is thought to be a relatively rare condition in which malaria parasite is transmitted from the mother to the baby during pregnancy or at childbirth. This is so either because the babies were not routinely screened or due to difficulty in detecting the relatively scanty parasite in the newborn period. The study set out to document malaria parasitemia among the neonates in Akure, Ondo state.
Methods: Febrile babies admitted into the special care baby unit of University of Medical Sciences Teaching Hospital and Mother and Child Hospital, Akure were tested for malaria parasite using microscopy method and confirmed by nested PCR. Data were analysed using excel and SPSS version 25.0
Results: Nineteen percent of the babies were preterm, 81% were full term and the overall prevalence of malaria among them was 74.7% while prevalence of congenital malaria was 92.9% and prevalence of neonatal malaria was 54.1%. Plasmodium falciparum was the most prevalent infecting species (98.3%), first born babies and male children were significantly more infected (p=0.001).
Conclusion: Prevalence of malaria was very high in this study. Malaria infection in the neonates can be difficult to diagnose because the clinical features are nonspecific and parasitaemia often scanty. Screening for malaria parasite should therefore be done as part of routing tests for the neonates.
Metrics
References
Oluwafemi RO. Clinical profile and short-term outcome of malaria in febrile under-five children in a secondary health facility. Ann Health Res. 2023;9(2):98-107. DOI: https://doi.org/10.30442/ahr.0902-02-195
Olupot P, Eregu EIE, Naizuli K, Ikiror J, Acom L, Burgoine K. Neonatal and congenital malaria: a case series in malaria endemic eastern Uganda. Malaria J. 2018;17:171-6. DOI: https://doi.org/10.1186/s12936-018-2327-0
Oduwole OA, Ejezie GC, Odey FA, Oringanje CM, Nwakanma D, Bello S, et al. Congenital Malaria in Calabar, Nigeria: The Molecular Perspective. Am J Trop Med Hyg. 2011;84(3):386–9. DOI: https://doi.org/10.4269/ajtmh.2011.10-0253
Regasa MT, Shibiru T, Tilahun T, Bayisa G, Negari GK. Congenital malaria in a 20-day-old neonate: a case report and literature review. Res Rep Neonatol. 2024;14:39-42. DOI: https://doi.org/10.2147/RRN.S452965
Afolabi OJ, Oluwafemi OR, Oniya MO. Pfmdr 1 and kelch 13 genes distribution among children that are 5 years and below in Akure, Nigeria. J Parasit Dis. 2022;3:1-9. DOI: https://doi.org/10.21203/rs.3.rs-1906304/v1
Mukhtar MY, Lesi FEA, Iroha EU, Egri-Okwaji MTC, Mafe AG. Congenital malaria among inborn babies at a tertiary centre in Lagos, Nigeria. J Trop Pediatr. 2006;52:19-23 . DOI: https://doi.org/10.1093/tropej/fmi044
D'Alessandro U, Ubben D, Hamed K, Ceesay SJ, Okebe J, Taal M, et al. Malaria in infants aged less than six months-is it an area of unmet medical need. Malar J. 2012;11:400. DOI: https://doi.org/10.1186/1475-2875-11-400
Nyarko SH, Cobblah A. Sociodemographic Determinants of Malaria among UnderFive Children in Ghana. J Malaria Res Treat. 2014;30(4):30-6. DOI: https://doi.org/10.1155/2014/304361
Oluwafemi RO, Afolabi OJ, Oniya MO. Prevalence of malaria among under-5 children in a secondary care level, Ondo State, Nigeria. European J Clin Med. 2024;5(2):8–13. DOI: https://doi.org/10.24018/clinicmed.2024.5.2.328
World Health Organization. Giemsa staining of malaria blood films: malaria microscopy standard operating procedure. World health organization. 2022.
Grabias B, Essuman E, Quakyi IA, Kumar S. Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein-1 gene amplifier. Mal J. 2019;18:116. DOI: https://doi.org/10.1186/s12936-019-2743-9
Mohan K, Omar BJ, Chacham S. Malaria in newborn: A missed entity for primary care physician. J Family Med Prim Care. 2023;12(8):1511-5. DOI: https://doi.org/10.4103/jfmpc.jfmpc_2332_22
Danwang C, Bigna JJ, Nzalie RNT, Robert A. Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis. Malar J. 2020;19:312. DOI: https://doi.org/10.1186/s12936-020-03373-8
Hyacinth HI, Oguche S, Yil-gwan CS. Summary description of 24 cases of neonatal malaria seen at tertiary health center in Nigeria. Iran J Pediatr. 2012;2:87–915.
Okoli CA, Okolo SN, Collins JC. Plasmodium falciparum infection among neonatesin the North Central region of Nigeria. J Infect Dev Ctries. 2013;7:365–71. DOI: https://doi.org/10.3855/jidc.2775
Diala U, Onyedibe K, Ofakunrin A, Diala O, Toma B, Egah D, et al. Prevalence, Clinical Features and Outcome of Neonatal Malaria in Two Major Hospitals in Jos, North-Central Nigeria. Advances in Infect Dis. 2017;7:55-69. DOI: https://doi.org/10.4236/aid.2017.73007
Tesso ZG, Gossaye TY, Bekana DS. Plasmodium falciparum neonatal malaria with atypical presentation: a case series from southwestern Ethiopia. Malar J. 2023;23:178. DOI: https://doi.org/10.1186/s12936-024-04987-y
Kumar G, Shankar H. Unravelling the situation of malaria misdiagnosis in India: Its adverse impact and management strategies. Asian Pac J Trop Med. 2022;15:290–2. DOI: https://doi.org/10.4103/1995-7645.351762
Orogade AA. Neonatal malaria in a mesoendemic malaria area of Northern Nigeria. Annals of African Med. 2004;3:170-3.
Oluwafemi RO, Afolabi OJ, Oniya OM. Malaria Parasitemia and Preventive Measures Among Children 5 Years and below in SouthWest, Nigeria. Global J Res Med Sci. 2024;4(1):96-103.
Nfor NO, Senyuy DT. Malaria among febrile neonates attending the neonatology unit of the Bamenda regional hospital. Parasite Epidemiol Control. 2020;11:184. DOI: https://doi.org/10.1016/j.parepi.2020.e00184
Obu HA, Ibe BC. Neonatal malaria in Gambia. Ann Med Health Sci Res. 2011;1:45-54.
Bilal JA, Malik EE, Nafeesah AA, Adam I. Global prevalence of congenital malaria: A systematic review and meta-analysis. European J Obst Gynecol Reprod Biol. 2020;252:534-42. DOI: https://doi.org/10.1016/j.ejogrb.2020.06.025