DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20170994

Lipid profile in school children: study from a District of Uttar Pradesh, India

Utkarsh Bansal, Ekansh Rathoria, Abhishek Gupta, Nyay Bhai Gupta, Shwinka Agarwal, Ravindra Ahuja, Smriti Ahuja, Richa Rathoria

Abstract


Background:Lipid imbalance when diagnosed in childhood, can forecast the development of atherosclerosis in adulthood and its complications. Therefore, early detection of dyslipidemia should begin in childhood and it should lead to long-term prevention of atherosclerosis by controlling the risk factors. The Objectives of the study were to study lipid profile of children in the age group of 10-19 years and the prevalence of dyslipidemia among them.

Methods: This is a cross-sectional study, which was conducted in 300 children aged 10 to 19 years, of either sex, from schools of Barabanki. After getting consent from school authorities, children and their parents, a detailed history was taken with a pre-designed pro forma and fasting blood samples were analyzed for lipid profile.

Results:Mean total cholesterol (TC) for boys and girls were 161.06±33.14 mg/dl and 164.68±33.53 mg/dl, LDL-C 99.35±27.41 mg/dl and 101.71±26.44 mg/dl, HDL-C 42.76±5.78 mg/dl and 43.93±5.68 mg/dl, VLDL-C 18.94±4.47 mg/dl and 19.04±4.97 mg/dl and triglycerides (TG) 94.69±22.34 mg/dl and 95.20±24.83 mg/dl respectively. Serum TC, TG, LDL-C, VLDL-C and HDL-C levels were higher in girls than in boys for all age groups. 26.55% boys and 25.20% girls had TC levels above 190 mg/dl. The overall results revealed that 26.0% of children had hypercholesterolemia.

Conclusions:The study presents age- and sex-related findings about the dynamics of changes in serum lipid levels in children. Significant number of children had hypercholesterolemia.


Keywords


Atherosclerosis, Dyslipidemia, Lipid profile

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References


Glueck CJ, Fallat RW, Tsang R, Buncher CR. Hyperlipidemia in progeny of parents with myocardial infarction before age 50. Am J Dis Child. 1974;127(1):70-5.

Raitakari OT, Porkka KV, Viikari JS, Ronnemaa T, Akerblom HK. Clustering of risk factors for coronary heart disease in children and adolescents. The Cardiovascular Risk in Young Finns Study. Acta Paediatr. 1994;83(9):935-40.

Holman RL, McGill Jr HC, Strong JP, Geer JC. The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the 20th century. Am J Pathol. 1958;34(2):209-35.

Enos WF, Holmes RH, Beyer J. Coronary disease among United States soldiers killed in action in Korea: preliminary report. JAMA. 1953;152(12):1090-3.

Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis Dallas, Tex. 1988;(1):I19-32.

Gidding SS, Bao W, Srinivasan SR, Berenson GS. Effects of secular trends in obesity on coronary risk factors in children: the Bogalusa Heart Study. J. Pediatr. 1995;127(6):868-74.

Strong JP, McGill HC Jr. The pediatric aspects of atherosclerosis. J Atheroscler Res. 1969;9(3):251-65.

Khalil A, Gupta S, Madan A, Venkatesan M. Lipid profile norms in Indian children. Indian Pediatr. 1995;32(11):1177-80.

Singh D, Anand NK, Singh P. Lipid profile in children aged 5 to 15 years with parental history of ischemic heart disease, hypertension and diabetes mellitus. Indian Pediatr. 2002;39(2):168-72.

Khalil A, Prakash V, Bhattacharjee J. Insulin resistance and lipid profile in the children of young ischemic parents. Indian Pediatr. 2003;40(10):946-50.

Gulati S, Saxena A. Study of lipid profile in children of parents with premature coronary artery disease. Indian Pediatr. 2003;40(6):556-60.

Madhavan M, Pandey RM, Misra A, Vikram NK, Dhingra V, Luthra K, et al. Centile values for serum lipids and blood pressure for Asian Indian adolescents. Lipids Health Dis. 2005;29(4):20.

National Cholesterol Education Program (NCEP): Highlights of the report of the expert panel on Blood cholesterol levels in children and adolescents. Pediatrics 1992;89:495-501.

deOnis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bulletin of the World Health Organization. 2007;85:660-7.

Roeschlau P, Bernt E, Gruber W. Enzymatic determination of total cholesterol in serum. Clin. Chem. Clin. Biochem. 1974;12(5):226-8.

Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;28(10):2077-80.

McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 1983;29(3):538-42.

Burstein MS, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970;11(6):583-95.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502.

Jha P, Enas E, Yusuf S. Coronary Artery Disease in Asian Indians: Prevalence and Risk Factors. Asian Am Pac. Islander J Health 1992;1(2):163-75.

Brook CG. Cardiovascular risk factors in children: the early natural history of atherosclerosis and essential hypertension. Arch Dis Child. 1981;56(6):488.

Back GI, Caramelli B, Pellanda L, Duncan B, Mattos S, Fonseca FH. I guidelines of prevention of atherosclerosis in childhood and adolescence. Arq Bras Cardiol. 2005;85(6):4-36.

Wajid Ali S, Buch NA, Masood H. Serum lipid profile in Kashmiri children. Indian J Physiol Pharmacol. 1995;39(1):55-8.

Fukushige J, Igarashi H, Ueda K, Akazawa K, Nose Y. Serum cholesterol levels in school‐aged Japanese children: The Hisayama study. Pediatr Int. 1996;38(1):22-7.

Dholpuria R, Raja S, Gupta BK, Chahar CK, Panwar RB, Gupta R, et al. Atherosclerotic risk factors in adolescents. Indian J Pediatr. 2007;74(9):823-6.

Uçar B, Kiliç Z, Dinleyici EC, Colak O, Güneş E. Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiyol Derg. 2007;7(4):415-21.

Nijaguna.N, Vani H.N, Niranjan H.S, Suresh T.N, Sanjeeva G.N. Study of lipid profile and prevalence of dyslipidemia in adolescent school children from Karnataka. Int J Pharm Biol Sci. 2015;5(1):79-85.

Gupta R, Goyle A, Kashyap S, Agarwal M, Consul R, Jain BK. Prevalence of atherosclerosis risk factors in adolescent school children. Indian Heart J. 1998;50(5):511-5.

Alberty RR, Albertyova D. Serum lipid growth curves for children and adolescents in predicting adult dyslipidemia (Data from the Slovak Lipid Community Study. Adv Biol Chem. 2013;3(05):419.

Knuiman JT, West CE, Katan MB, Hautvast JG. Total cholesterol and high density lipoprotein cholesterol levels in populations differing in fat and carbohydrate intake. Arterioscler Thromb Vasc Biol. 1987;7(6):612-9.

Posadas-Sanchez R, Posadas-Romero C, Zamora-Gonzalez J, Mendoza-Perez E, Cardoso-Saldana G, Yamamoto-Kimura L. Lipid and lipoprotein profiles and prevalence of dyslipidemia in Mexican adolescents. Metabolism. 2007;56(12):1666-72.

Moura EC, de Castro CM, Mellin AS, de Figueiredo DB. Lipid profile among school children in Campinas, Brazil. Rev Saude Publica. 2000;34(5):499-505.

Moran A, Jacobs DR, Steinberger J, Hong CP, Prineas R, Luepker R, et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes. 1999;48(10):2039-44.

Dhingra V, Chatterjee A, Guleria R, Sharma R, Pandey RM, Talwar KK, et al. Adverse physical activity pattern in urban adolescents. J Assoc Physicians India. 2002;50:1521.

Robinson JG, Boland LL, McGovern PG, Folsom AR. ARIC Investigators. A comparison of NCEP and absolute risk stratification methods for lipid‐lowering therapy in middle aged adults: the ARIC study. Prev Cardiol. 2001;4(4):148-57.

Boden WE. High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from framingham to the veterans affairs high-density lipoprotein intervention trial. ‎Am J Cardiol. 2000;86(12):19-22.

Li Z, Yang R, Xu G, Xia T. Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing. Clin Chem. 2005;51(1):144-50.

Bahar A, Sevgican U, Karademir F, Gocmen I. Serum cholesterol, triglyceride, VLDL-c, LDL-c, and HDL-c levels in healthy children. Tohoku J Exp Med. 2003;201(2):75-80.

Williams P, Robinson D, Bailey A. High density lipoprotein and coronary risk factors in normal men. Lancet. 1979;1:72-5.

Castelli WP, Abbott RD, McNamara PM. Summary estimate of cholesterol used to predict coronary heart disease. Circulation. 1983;67(4):730-4.