DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20170993

Hyponatremia: a diagnostic marker for the diagnosis of Rickettsial diseases

Channabasavaraj Hullatti, Latha G. S., Veeresh Babu B. V.

Abstract


Background: Rickettsial infections are re-emerging in Indian subcontinent, it is difficult to diagnose among children’s in seasonal conditions, an early recognition with clinical and laboratory findings give good response to treatment and avoid unnecessary investigations in limited resources.

Methods: The case sheets of all 60 children’s aged <18 years were retrieved and reviewed retrospectively, who are both clinically and serologically confirmed as Rickettsial disease cases were included in this study.

Results: Fever for more than 1week was the most common manifestation, followed by splenomegaly (40%), rash (33%), cough (30%), altered sensorium (16%), and seizures (10%). In laboratory investigation Hyponatremia (56%), elevated liver enzymes without significant rise of bilirubin (28%), hypoalbuminemia (28%), and thrombocytopenia (38%). Patients were treated with Doxycycline, Azithromycin. There was no mortality.

Conclusions: Rickettsial infections are notoriously difficult to diagnose in seasonal condition, untreated cases can have fatality as high as 30-35%, when diagnosed, it is easily treated. Majority of case showed Hyponatremia, may be used as marker in limited diagnostic laboratory facilities.  


Keywords


Hyponatremia, Rickettsial diseases

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