Alpha thalassemia trait in a child with juvenile diabetes: a case report

Authors

  • Manaal Kunnummal Department of Paediatrics, Pushpagiri Institute of Medical Sciences, Thiruvalla, Pathanamthitta, Kerala, India
  • Bincy Philip Department of Paediatrics, Pushpagiri Institute of Medical Sciences, Thiruvalla, Pathanamthitta, Kerala, India
  • Carol Sara Cherian Department of Paediatrics, Pushpagiri Institute of Medical Sciences, Thiruvalla, Pathanamthitta, Kerala, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20251109

Keywords:

α-Thalassemia trait, Microcytic hypochromic anemia, Type 1 diabetes mellitus, Hemoglobinopathy

Abstract

Alpha thalassemia trait (two missing α-globin genes) manifests as a microcytic anaemia that can be mistaken for iron-deficiency anaemia. A 12‑year‑old female child, who is a known case of type 1 diabetes mellitus presented with persistent microcytic hypochromic anaemia which failed to improve even after iron therapy. She was evaluated for her low haemoglobin values with the peripheral smear showing microcytic hypochromic anaemia which eventually was diagnosed as alpha thalassemia trait. This case reiterates the association between a metabolic disorder and a haemoglobinopathy, which is rarely reported in children.

Metrics

Metrics Loading ...

References

Cloete L. Diabetes mellitus: an overview of the types, symptoms, complications and management. Nurs Stand. 2022;37(1):61-6. DOI: https://doi.org/10.7748/ns.2021.e11709

Weatherall DJ. The Evolving Spectrum of the Epidemiology of Thalassemia. Hematol Oncol Clin North Am. 2018;32(2):165-75. DOI: https://doi.org/10.1016/j.hoc.2017.11.008

Tan JAMA, Lee PC, Wee YC, Tan KL, Mahali NF, George E, et al. High Prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in East Malaysia: Challenges in Providing Effective Health Care for an Indigenous Group. J Biomed Biotechnol. 2010;2010:1-5. DOI: https://doi.org/10.1155/2010/706872

Rosnah B, Rosline H, Zaidah AW, Noor Haslina MN, Marini R, Shafini MY, et al. Detection of Common Deletional Alpha-Thalassemia Spectrum by Molecular Technique in Kelantan, Northeastern Malaysia. ISRN Hematol. 2012;2012:1-3. DOI: https://doi.org/10.5402/2012/462969

Harewood J, Azevedo AM. Alpha Thalassemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2025.

Ziegler EE. Consumption of cow’s milk as a cause of iron deficiency in infants and toddlers. Nutr Rev. 2011;69:S37-42. DOI: https://doi.org/10.1111/j.1753-4887.2011.00431.x

Chui DHK, Waye JS. Hydrops Fetalis Caused by α-Thalassemia: An Emerging Health Care Problem. Blood. 1998;91(7):2213-22. DOI: https://doi.org/10.1182/blood.V91.7.2213.2213_2213_2222

Couper JJ, Harrison LC. Controversies in medicine: redefining the diagnosis of type 1 diabetes. Med J Aust. 2019;211(4):157. DOI: https://doi.org/10.5694/mja2.50284

Ize-Ludlow D, Sperling MA. The Classification of Diabetes Mellitus: A Conceptual Framework. Pediatr Clin North Am. 2005;52(6):1533-52. DOI: https://doi.org/10.1016/j.pcl.2005.07.001

Evangelidis P, Venou TM, Fani B, Vlachaki E, Gavriilaki E. Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron? Int J Mol Sci. 2023;24(22):16263. DOI: https://doi.org/10.3390/ijms242216263

Hashemieh M, Radfar M, Azarkeivan A, Noghabaei G, Sheibani K. T2* Magnetic Resonance Imaging Study of Pancreatic Iron Overload and its Relation With the Diabetic State in Thalassemic Patients. J Pediatr Hematol Oncol. 2017;39(5):337-40. DOI: https://doi.org/10.1097/MPH.0000000000000767

Bahar A, Kashi Z, Sohrab M, Kosaryan M, Janbabai G. Relationship between beta-globin gene carrier state and insulin resistance. J Diabetes Metab Disord. 2012;11(1):22. DOI: https://doi.org/10.1186/2251-6581-11-22

Gunton JE, McElduff A. Hemoglobinopathies and HbA(1c) measurement. Diabetes Care. 2000;23(8):1197-8. DOI: https://doi.org/10.2337/diacare.23.8.1197

Holt GS. Hemoglobinopathies Affect Hemoglobin A_1C Measurement. Ann Intern Med. 1991;115(1):68. DOI: https://doi.org/10.7326/0003-4819-115-1-68_2

Bahar A, Shekarriz R, Janbabai G, Shirzad R, Aarabi M, Kashi Z. Insulin resistance, impaired glucose tolerance and alpha-thalassemia carrier state. J Diabetes Metab Disord. 2015;14(1):2. DOI: https://doi.org/10.1186/s40200-015-0129-2

Lao TT, Ho LF. α-Thalassaemia trait and gestational diabetes mellitus in Hong Kong. Diabetologia. 2001;44(8):966-71. DOI: https://doi.org/10.1007/s001250100594

Downloads

Published

2025-04-24

How to Cite

Kunnummal, M., Philip, B., & Cherian, C. S. (2025). Alpha thalassemia trait in a child with juvenile diabetes: a case report. International Journal of Contemporary Pediatrics, 12(5), 842–845. https://doi.org/10.18203/2349-3291.ijcp20251109

Issue

Section

Case Reports