Comparative study of micro ESR with CRP and blood culture sensitivity
DOI:
https://doi.org/10.18203/2349-3291.ijcp20243473Keywords:
Blood culture sensitivity, C-reactive protein, Micro-erythrocyte sedimentation rate, Neonatal sepsisAbstract
Background: Neonatal sepsis is one of the leading causes of morbidity and mortality among neonates in India. Indian association of paediatrics has developed sepsis screen which is useful for early diagnosis. To test the reliability of micro ESR as bedside tool in early diagnosis of neonatal sepsis we conducted this study. Comparison of Micro-erythrocyte sedimentation rate (micro ESR) with C-reactive protein (CRP) and blood culture sensitivity in neonatal sepsis. To establish a relation between severity of sepsis and Micro-erythrocyte sedimentation rate.
Methods: This is a cross sectional study done at neonatal intensive care unit (NICU), at our institute over a period of six months. Fifty neonates with risk factors for sepsis and who had a positive sepsis screen were enrolled prospectively into the study.
Results: Out of 50 samples collected, micro ESR (>15 mm/hour) was positive in 12 cases (24%) and CRP was positive in 18 cases (36%). After procuring the blood culture report, 48 cases had neonatal sepsis (84%). Our study showed that micro-ESR as a bedside test had a positive correlation with mortality (p value <0.001) when compared with CRP values (p value=0.546) in neonatal sepsis. As expected, elevated micro ESR and high CRP value had 100% correlation but was not statistically significant (p=0.319). In all the 12 cases with raised micro ESR had 100% blood culture positivity but significance could not be established.
Conclusions: Micro-ESR had a significant correlation with mortality in neonatal sepsis.
References
Chandrasekaran A, Chawla D, Kumar P, Sankar MJ, Shah S, Sivanandan S, et al. Clinical practice guidelines. diagnosis and management of neonatal sepsis. National Neonatology Forum. 2021;2:95-206.
Gollehon NS, Aslam M. Neonatal sepsis clinical presentation. 2019. Available at: https://emedicine.medscape.com. Accessed on 23 August 2024.
Santhanam S, Anand P, Mohanty PK, Kumar R, Gupta P, Saxena V. Neonatal Sepsis Standard Treatment Guidelines 2022. Upendra Kinjawadekar IAP President-Elect 2022 under the Auspices of IAP Action Plan 2022. IAP STG Neonatal Sepsis. 2022.
Kutty GA, Prabhu AS. Role of Micro-ESR in the Evaluation of Suspected Sepsis in Neonates. Int J Sci Res. 2013;4(2):2319-7064.
Adler SM, Denton RL. The Erytrhrocyte sedimentation Rate in newborn period. Journal of Pediatrics. 1975;8(6):942-8.
Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, et al. Neonatal sepsis: need for consensus definition, collaboration and core outcomes. Pediatric Res. 2020;88(1):2-4.
Walliullah SM, Islam MN, Siddika M, Hossain MA, Chowdhury AK. Role of micro-ESR and I/T ratio in the early diagnosis of neonatal sepsis. Mymensingh Med J. 2009;18(1):56-61.
Kafle R, Yadav J, Gupta BK, Gupta BK. Role of micro ESR in the evaluation of neonatal sepsis. J Uni Coll Med Sci. 2019;7(2):25-9.
Kutty GA, Prabhu AS. Role of Micro-ESR in the Evaluation of Suspected Sepsis in Neonates. Int J Sci Res. 2015;4(8):311-4.
Gugnani P, Arora M, Devi P, Neki NS. Correlation between CRP and Blood Culture in Evaluation of Neonatal Sepsis. Ann Int Med Dent Res. 2019;5(2):14-7.
Manandhar SR, Basnet R. Micro-erythrocyte sedimentation rate in neonatal sepsis of a tertiary hospital: a descriptive cross-sectional study. J Nepal Med Assoc. 2020;58(226):377-82.
Babu TA, Arundhathi S, Vijayadevagaran V, Sharmila V, Kalidoss VK. Comparative efficacy of micro-erythrocyte sedimentation rate (m-ESR) and C-reactive protein (CRP) as a neonatal septic screening marker. A single-center, retrospective observational study. Egypt Pediat Asso Gazette. 2023;71(1):1-5.
