Study of clinical profile and outcome of viral hepatitis in children with reference to liver function test during covid pandemic admitted at tertiary care hospital

Authors

  • Pathik U. Patel Department of Paediatric, GMERS Medical College and Hospital, Valsad, Gujarat, India
  • Chirag D. Shah Department of Paediatric, BJ Medical College and Hospital, Ahmedabad, Gujarat, India
  • Abhishek M. B. Department of Paediatric, Shri Devraj Urs Medical College, Kolar, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20243469

Keywords:

COVID-19, LFT, Viral hepatitis

Abstract

Background: Viral hepatitis is major health problem in both developing and developed country affecting millions of children worldwide. Viral hepatitis defined as inflammation of liver due to hepatotropic and/or non-hepatotropic viruses. Extent of disease vary from acute to chronic which ranges from asymptomatic to fatal acute and on other side from subclinical persistent to rapid progressive chronic disease. Aim of study was proportion and etiology with clinical profile and outcome relation to liver function test (LFT).

Methods: This is retrospective observation study done at civil hospital, Ahmedabad during June 2019 to May 2021 during covid era in admitted patients from age of 6 month to 12 year diagnosed as viral hepatitis. Data collected from medical records and investigation from laboratory data.

Results: In my study, Viral hepatitis was m/c seen in age group of 5 to 10 year in lower socioeconomic class with most common hepatotropic virus was hepatitis A (51.79%) and non-hepatotropic virus was dengue virus (17.86%). Most common presenting complain was fever (93.75%) and sign was jaundice (87.5%). Altered liver function seen in 96.57% patients. Outcome with 4.46% death due to covid19 virus.

Conclusions: In my study during covid19 pandemic, still most common cause for viral hepatitis was hepatotropic virus–HEPATITIS A in admitted patients at tertiary care hospital. But case fatality rate was noted highest in COVID-19 virus among total death.

References

Mrs. Viviana Dissertation on To access the effectiveness of structured teaching program on knowledge and attitude regarding Hepatitis among patients attending outpatient’s department of gastroenterology at selected hospital Selam. Available at: https://core.ac.uk/download/pdf/ 235671186.pdf. Accessed on 12 September 2024.

Castaneda D, Gonzalez AJ, Alomari M, Tandon K, Zervos XB. From hepatitis A to E: A critical review of viral hepatitis. World J Gastroenterol 2021;27(16):1691-715.

Viral Hepatitis- The Silent Disease Facts and Treatment Guidelines Directorate General of Health Service, Ministry of Health & Family Welfare

Government of India. Available at: https://ncdc.mohfw.gov.in/wp-content/uploads/ 2024/04/guideline_hep20158117187417.pdf. Accessed on 12 September 2024.

Nelson textbook of paediatrics International. 21 Edition. 2:385.

Rawat. COVID-19 Associated Hepatitis in children (CAH-C) during the second wave of SARS-CoV-2 infection in central India: Is it a complication or transient phenomenon. Covid-19 SARS-CoV-2 preprint from medRxiv and bioRxiv COVID-19 Associated Hepatitis in Children (CAH-C) during the second wave of SARS-CoV-2 infections in Central India: Is it a complication or transient phenomenon. Available at: https://www.medrxiv.org. Accessed on 12 August 2024.

Girish N, Sunil B, Ranganatha A, Devaranavadagi A. Clinical study of viral hepatitis in children: a prospective hospital-based study. Available at: https://www.researchgate.net/publication. Accessed on 24 August 2024.

Das S, Deka A, Biswas T. Clinical profile of Acute Viral Hepatitis in children-Southern Assam. JMSCR. 2021;9(3):111-8.

Behera MR, Patnaik L. Clinico-biochemical profile and etiology of acute viral hepatitis in hospitalized children: A study from Eastern India. Avialable at: https://www.researchgate.net. Accessed on 24 August 2024.

Sharma CM, Gupta S, Aggarwal B, Chaudhary P. Acute viral hepatitis in children: a prospective hospital-based study. Available at: https://www.researchgate.net/publication. Accessed on 18bAugust 2024.

Biradar PA, Tambe AS, Rathi SP, Junare PR, Rathi PM. Spectrum of viral hepatitis in hospitalized children in western India. Trop Doct. 2023;53(1):109-12.

Rawat SK, Asati AA, Mishra N, Jain A, Ratho RK. Identification of COVID-19-Associated Hepatitis in children as an emerging complication in the wake of SARS-CoV-2 Infections: Ambispective Observational Study. JMIRx Med. 2024;5:48629.

Downloads

Published

2024-11-25

Issue

Section

Original Research Articles