Uncommon association of tuberculosis with deep vein thrombosis in a child: a case report
DOI:
https://doi.org/10.18203/2349-3291.ijcp20243483Keywords:
Disseminated tuberculosis, Deep vein thrombosis, LymphadenopathyAbstract
Tuberculosis (TB) is a major global health issue, particularly in developing countries. While TB commonly affects the lungs, it can spread to nearly any organ system, leading to a range of complications. One rare extrapulmonary manifestation of TB is deep vein thrombosis (DVT), which is even more rarely reported in children. We report a case of a 13-year-old girl with progressive, painful swelling in right lower limb, accompanied by fever, cough and lymphadenopathy. Diagnostic imaging identified DVT in the right external iliac vein. Further investigation confirmed Mycobacterium tuberculosis infection. She was treated with anti-tubercular medication and therapeutic anticoagulation. Although uncommon, this case underscores the importance of recognizing this serious complication and need for timely diagnosis and treatment.
References
Moheimani F, Jackson DE. Venous thromboembolism: classification, risk factors, diagnosis, and management. ISRN Hematol. 2011;2011:124610.
Gupta A, Dixit R. Pulmonary tuberculosis: a neglected risk factor for deep venous thrombosis. Int J Mycobacteriol. 2017;6(2):184-6.
Kechaou I, Cherif E, Ben Hassine L, Khalfallah N. Deep vein thrombosis and tuberculosis: a causative link? BMJ Case Rep. 2014;2014:bcr2013200807.
Gupta A, Mrigpuri P, Faye A, Bandyopadhyay D, Singla R. Pulmonary tuberculosis - an emerging risk factor for venous thromboembolism: a case series and review of literature. Lung India. 2017;34(1):65-9.
Sangani J, Mukherjee S, Biswas S, Chaudhuri T, Ghosh G. Tuberculosis and acute deep vein thrombosis in a paediatric case. J Clin Diagn Res. 2015;9(6):SD01-2.
Gathwala G, Dalal P, Gehlawat V, Singh J, Arya V. A case of deep vein thrombosis and intracranial sinus thrombosis: possible rare complications of childhood abdominal tuberculosis. Sultan Qaboos Univ Med J. 2016;16(4):e516-9.
Saini R, Mishra A, Gupta KK, Kallani M. Deep vein thrombosis in patient with pulmonary tuberculosis: a rare and interesting causative link? Int J Adv Med. 2019;6:542-6.
Siddiqui SA, Khan M, Khan I. Role of proinflammatory cytokines in deep vein thrombosis. Thromb Res. 2013;132(2):156-60.
Prasad K, Singh N, Rao PS. Antiphospholipid antibodies and deep vein thrombosis in tuberculosis patients. Clin Appl Thromb Hemost. 2011;17(6):652-7.
White NW. Venous thrombosis and rifampicin. Lancet. 1989;2(8660):434-5.