Neonatal seizures-clinical profile and evaluation of associated biochemical abnormalities in a tertiary newborn intensive care unit
DOI:
https://doi.org/10.18203/2349-3291.ijcp20243090Keywords:
Neonatal, Seizures, Subtle, Biochemical, Hypoglycaemia, HypocalcaemiaAbstract
Background: Seizure is the most common sign of neurological dysfunction in a neonate. Seizures increase the risk of impaired neurologic development and also the risk of death. Neonatal seizures per se are not a disease entity but rather a symptom commonly related to significant underlying disorders.
Methods: It is a non-randomized prospective observational study conducted in the NICU at Ranees hospital, government Pudukkottai medical college, Pudukkottai from December 2023 to June 2024. Both intramural and extramural neonates with seizures were included in the study as per protocol and evaluated.
Results: Out of the 152 neonates included in the study, 64% had onset of seizure in the first day of life. A slight male preponderance in seizure incidence is noted. Hypoxic ischaemic encephalopathy is the commonest aetiology followed by biochemical abnormalities. Subtle seizures are the commonest single type of seizures and subtle + multifocal combined are the commonest combination type seen. Hypoglycaemia, hypocalcaemia and hypomagnesaemia are the common biochemical abnormalities noted.
Conclusions: Early recognition of seizures and early correction of the Biochemical abnormalities is crucial to prevent neonatal morbidity and mortality.
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References
Laroia N. Current controversies in the diagnosis and management of neonatal seizures. Indian Pediatr. 2000;37(4):367-72.
Levene M. The clinical conundrum of neonatal seizures. Arch Dis Childhood Fetal Neonatal Ped. 2002;86(2):F75.
NA. Neonatal perinatal medicine-Disease of the fetus and infant. Moseby St Louis. 2002;53(8):696.
NA. Neonatal morbidity and mortality report of national neonatal perinatal database. Indian Paediatr. 1997;34:1038-40.
Strober JB, Beinkowstki RS. The incidence of acute and remote seizures in children with intraventricular haemorrhage. Clin Pediatr. 1997;36:643.
Volpe JJ. Neurology of the newborn. Major Probl Clin Pediatr. 1981;22:1-648.
Carison C. Neonatal seizures central lines. XXX. 2000;16:7.
McGrath JM, Developmental physiology of the neurological system central lines. XXX. 2000;16:1.
Groves A, James B, Ramasethu J. Avery and McDonald G. Avery & MacDonald's Neonatology: Pathophysiology and Management of the Newborn. 8th ed, Wolters Kluwer Health. 2006.
Brown JK. Convulsions in newborn period. Dev Med Child Neurol. 1973;15(6):823-46.
Hill A, Volpe JJ. Neurological disorders-Avery GB, Fletcher MA, McDonald MG, 4th edn neonatology pathophysiology and management of newborn. Philadelphia JB Lippincott company. 1994;1117-39.
Dasilva O, Gusman GMC, Yound GB, The value of standard electroencephalograms in the evaluation of the newborn with recurrent apnoea. J Perinatal. 1998;18:377.
Erikkson M, Zetterstrom R. Neonatal convulsion incidence in Stockholm area. Acta Paediatric Scand. 1976;68:607-11.
Sood A, Grover N, Sharma R. Biochemical abnormalities in neonatal seizures. Indian J Paediatr. 2003;70(3):221-4.
Calciolari G, Perlman JM, Volpe JJ. Seizures in neonatal intensive care unit of 1980. Clin Paediatric. 1988;27(3):119-23.
Lambroso ct 2002, in Ascordils epilepsy in children. Alexi arxzigmanglou. 2004.
Shan G, Singh MK, Budhathoki S, Kalakheti B, Baral D. Study of clinico-biochemical profile of neonatal seizure, 2007 at Koirala Institute of Health Sciences, Dharan, Nepal. J Nepal Paediatric Society. 2008;28(1):7-9.
Mirzahi FM, Kellaway P. Characterisation and classification of neonatal seizures. Neurology. 1986;37(12);1837-44.
Kumar A, Gupta VJS, Kachakunn PN. Single biochemical abnormalities in neonatal seizures. Indian Paediatr. 1995;32(2);424-8.
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