Comparison of serum electrolytes in children with febrile seizures to febrile children without seizures: a case control study

K. Jayasurya; Pankaj Kumar Singhal; Manav Gaba; Gaurav Mathur

doi:10.18203/2349-3291.ijcp20243087

Authors

K. Jayasurya Department of Pediatrics, Jaykaylon Mother and Child Hospital, Government Medical College, Kota, India
Pankaj Kumar Singhal Department of Pediatrics, Jaykaylon Mother and Child Hospital, Government Medical College, Kota, India
Manav Gaba Department of Pediatrics, Jaykaylon Mother and Child Hospital, Government Medical College, Kota, India
Gaurav Mathur Department of Pediatrics, Jaykaylon Mother and Child Hospital, Government Medical College, Kota, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20243087

Keywords:

Epilepsy, Febrile children, Febrile seizures, Paediatric neurology, Serum electrolytes

Abstract

Background: Febrile seizures (FS) are the most common type of seizures in children aged 6 to 60 months, occurring during fever episodes without underlying CNS infections or prior afebrile seizures. Electrolyte imbalances are thought to contribute to FS, but their exact role remains unclear. This study aimed to investigate the association between serum electrolyte levels (sodium, potassium, calcium and magnesium) in children with febrile seizures and compare them to febrile children without seizures.

Methods: A case-control study was conducted at the JK Lon Children and Mothers Hospital, Government Medical College, Kota, Rajasthan, over four months. Sixty-one children with febrile seizures were identified as cases and 60 febrile children without seizures served as controls. Data on sociodemographic and clinical parameters, including serum electrolyte levels, were collected. Chi-square tests and t-tests were used to analyse categorical and continuous variables, respectively.

Results: Significant differences were found in serum calcium and potassium levels between the two groups. Hypocalcemia was more prevalent in controls (75%) compared to cases (29.51%) (p=0.000), while hypokalemia was also higher in controls (35%) than in cases (6.56%) (p=0.000). No significant differences were observed in sodium and magnesium levels between the groups.

Conclusions: Calcium and potassium levels appear to be associated with the occurrence of febrile seizures in children, while sodium and magnesium levels showed no significant differences. Further studies are needed to clarify the role of electrolytes in FS pathogenesis.

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References

Steering committee on quality improvement and management on fs. febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;1;121(6):1281–6.

Vestergaard M, Obel C, Henriksen TB, Christensen J, Madsen KM, Ostergaard JR, et al. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J Clin Epidemiol. 2006;59(1):61–6.

Forsgren L, Sidenvall R, Blomquist HK, Heijbel J. A prospective incidence study of febrile convulsions. Acta Paediatr Scand. 1990;79(5):550–7.

Hauser WA. The prevalence and incidence of convulsive disorders in children. Epilepsia. 1994;35(2):1-6.

Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. Prevalence and recurrence in the first five years of life. Br Med J Clin Res Ed. 1985;4;290(6478):1307–10.

Leung AKC, Robson WLM. Febrile seizures. J Pediatr Health Care Off Publ Natl Assoc Pediatr Nurse Assoc Pract. 2007;21(4):250–5.

Iwasaki N, Nakayama J, Hamano K, Matsui A, Arinami T. Molecular genetics of febrile seizures. Epilepsia. 2002;43(9):32–5.

Castilla-Guerra L, del Carmen Fernández-Moreno M, López-Chozas JM, Fernández-Bolaños R. Electrolytes disturbances and seizures. Epilepsia. 2006;47(12):1990–8.

Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? - PubMed. Available at: https://pubmed.ncbi.nlm.nih.

Akbayram S, Cemek M, Büyükben A, Aymelek F, Karaman S, Yilmaz F, et al. Major and minor bio-element status in children with febrile seizure. Bratisl Lek Listy. 2012;113(7):421–3.

Namakin K, Zardast M, Sharifzadeh G, Bidar T, Zargarian S. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol. 2016;10(3):57–60.

Office of dietary supplements - magnesium. Available at: https://ods.od.nih.gov/factsheets.

Ghai essential paediatrics. CBS publishers and distributors private limited. 2019. Available at: https://books.google.co.in/books. Accessed on 21st March 2024.

Mohamed ZA, Tang C, Thokerunga E, Jimale AO, Fan J, Mohamed ZA, et al. Serum hypomagnesemia is associated with febrile seizures in young children. AIMS Neurosci. 2022;9(4):551–8.

Office of dietary supplements-calcium. 2020. Available at: https://ods.od.nih.gov/factsheets. Accessed on 17th March 2024.

Office of dietary supplements-potassium. Available at: https://ods.od.nih.gov/factsheets.

Viera AJ, Wouk N. Potassium Disorders: Hypokalemia and Hyperkalemia. Am Fam Physician. 2015;15;92(6):487–95.

Hinderling PH. The pharmacokinetics of potassium in humans is unusual. J Clin Pharmacol. 2016;56(10):1212–20.

Strazzullo P, Leclercq C. Sodium. Adv Nutr. 2014;6;5(2):188–90.

Sharma S, Singh N, Thimmaraju K, Tilak M. Assessment of ionized calcium status in febrile seizures. Int J Clin Biomed Res. 2018;31;4:35–7.

Chiarelli F, De Palma C, Verrotti A, Lombardi G, Domizio S. (Electrolytic changes in febrile convulsions). Pediatr Medica E Chir Med Surg Pediatr. 1985;7(2):249–52.

Papierkowski A, Mroczkowska-Juchkiewicz A, Pawłowska-Kamieniak A, Pasternak K. (Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions). Pol Merkuriusz Lek. 1999;1;6(33):138–40.

Kalyan DPSP, Prabhavati D. IT Medical Team. Int Op Access J. 2020. Available at: https://www.itmedicalteam.pl/ Accessed on 17th March 2024.