Clinico-epidemiological profile and outcomes of respiratory distress in newborns prospective observational study in a tertiary care

Innama Maryam; Syed Manazir Ali; Uzma Firdaus

doi:10.18203/2349-3291.ijcp20243086

Authors

Innama Maryam Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Syed Manazir Ali Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Uzma Firdaus Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20243086

Keywords:

Neonatal respiratory distress, Prevalence of neonatal respiratory distress, Risk factors of neonatal respiratory distress

Abstract

Background: Respiratory distress in neonates is common and can be a serious neonatal emergency. Globally prevalence of respiratory distress in newborns ranges from 0.64 to 88.4%. There are many risk factors predisposing neonates to respiratory distress. Respiratory distress syndrome (RDS) has high incidence in preterm neonates, while in late preterm and term neonates’ transient tachypnea of newborn (TTN) is common. In-hospital mortality due to respiratory distress varies between 0.21 to 57.3% world-wide.

Methods: Prospective observational study was conducted in neonatal section, JNMCH, AMU, Aligarh, U. P., India over a period of 2 years which included 200 neonates with respiratory distress out of 2806 neonates born on enrolment days. Various causes of respiratory distress, risk factors, immediate outcomes and prevalence of respiratory distress was observed and analysed.

Results: Prevalence of respiratory distress in newborns was 7.12% on enrollment days in our study with RDS as the leading cause of neonatal respiratory distress (n=71; 35.5%). Approximately 60% of study recruits were males (n=123) in which RDS (n=43) was commonest cause of respiratory distress. Out of 200 enrolled candidates in our study 167 (83.5%) were discharged and 33 (16.50%) expired with RDS (70%) being the major cause of mortality.

Conclusions: Neonatal respiratory distress is one of the common causes of NICU (Neonatal intensive care unit) admission. RDS was the most common cause of respiratory distress with maximum mortality in study recruits. Various fetal and maternal factors predisposed to neonatal respiratory distress and also influenced their immediate clinical outcomes.

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References

Aynalem YA, Mekonen H, Akalu TY, Habtewold TD, Endalamaw A, Petrucka PM, et al. Incidence of respiratory distress and its predictors among neonates admitted to the neonatal intensive care unit, Black Lion Specialized Hospital, Addis Ababa, Ethiopia. PloS One. 2020;15(7):e0235544.

Baseer KAA, Mohamed M, Abd-Elmawgood EA. Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt’, Annals of Global Health. 2020;86(1):22.

Tochie JN, Sibetcheu AT, Arrey-Ebot PE, Choukem SP. Global, Regional and National Trends in the Burden of Neonatal Respiratory Failure and essentials of its diagnosis and management from 1992 to 2022: a scoping review. Eur J Pediatr. 2024;183(1):9-50.

Definitions W. South East Asia Regional Neonatal-Perinatal Database’, World Health Organization (South-East Asia Region). 2016. Available at: http://www.newbornwhocc.org/pdf/database.pdf. Accessed on 25 September 2024.

Rijal P, Shrestha M. Scenario of neonatal respiratory distress in tertiary hospital. J Nepal Health Res Counc. 2018;16(2):131-5.

Lamichhane A, Panthee K, Gurung S. Clinical Profile of Neonates with Respiratory Distress in a Tertiary Care Hospital. J Nepal Med Assoc. 2019;57:412-5.

Yarci E, Canpolat FE. Evaluation of morbidities and complications of neonatal intensive care unit patients with respiratory disorders at different gestational ages. Am J Perinatol. 2022;29:1533-40.

Behera JN, Goutam V, Khamari DK. Prevalence and Outcome of Respiratory Distress in Newborn-A Tertiary Care Hospital Experience. JMSCR. 2020;08(2):668-73.

Sahoo MR, Vasundhara A, Rao MS, Alekhya J, Nagasree P. Clinicoetiological profile and risk assessment of newborn with respiratory distress in a tertiary care centre in South India. Int J Contemp Pediatr. 2015;2:433-9.

Raha BK, Alam M, Bhuiyan M. Spectrum of Respiratory Distress in Newborn: A Study from a Tertiary Care Military Hospital. J Bangladesh Coll Physicians Surg. 2020;39:4-8.

Parkash A, Haider N, Khoso ZA, Shaikh AS. Frequency, causes and outcome of neonates with respiratory distress admitted to Neonatal Intensive Care Unit, National Institute of Child Health, Karachi. J Pak Med Assoc. 2015;65(7):771-5.

Tochie JN, Choukem SP, Langmia RN, Barla E, Koki-Ndombo P. Neonatal respiratory distress in a reference neonatal unit in Cameroon: an analysis of prevalence, predictors, etiologies and outcomes. Pan Afr Med J. 2016;24:152.