Decoding the ovary-thyroid connection: a case report on intricacies of untreated hypothyroidism

Authors

  • Meenu Jose Department of Pediatrics, KIMSHEALTH, Trivandrum, Kerala, India
  • Sheeja Madhavan Department of Pediatric Endocrinology, KIMSHEALTH, Trivandrum, Kerala, India
  • Hridya Menon Department of Pediatric Surgery, KIMSHEALTH, Trivandrum, Kerala, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20242750

Keywords:

Hypothyroidism, Precocious puberty, Ovarian cyst, Thyroxine, Van Wyk-Grumbach syndrome

Abstract

Precocious puberty may be a rare presentation of untreated hypothyroidism, while delayed puberty is its norm. Van Wyk-Grumbach syndrome (VWGS) refers to the development of isosexual precocious pseudo puberty and multicystic enlarged ovaries in the presence of hypothyroidism. Here we report a case of an eight-year-old girl child who required emergency surgical intervention attributable to the aforementioned syndrome.

References

Gupta J, Lin-Su K. Van Wyk-Grumbach syndrome in a female pediatric patient with trisomy 21: a case report. Int J Pediatr Endocrinol. 2020;2020:2.

Van Wyk JJ, Grumbach MM. Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback. J Pediatr. 1960;57(3):416-35.

Torok KS, Arkachaisri T. Autoimmune thyroiditis in antinuclear antibody positive children without rheumatologic disease. Pediatr Rheumatol. 2010;8(1):15.

Sharma D, Dayal D, Gupta A, Saxena A. Premature menarche associated with primary hypothyroidism in a 5.5year old girl. Case Rep Endocrinol. 2011;2011:678305.

Bhansali A, Kashyap A, Lodha S, Kotwal N, Ganapathi B, Mittal B, et al. Isosexual precocity: uncommon presentation of a common disorder. Postgrad Med J. 2000;76(893):177.

Ryan GL, Feng X, d'Alva CB, Zhang M, VanVoorhis BJ, Pinto EM, et al. Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism J Clin Endocrinol Metab. 2007;92(6):2312-31.

Chemaitilly W, Thalassinos C, Edmond S, Thaibaud E. Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down syndrome. Arch Dis Childhood. 2003;88(4):330-1.

Downloads

Published

2024-09-24

Issue

Section

Case Reports