Epidemiological, clinical, therapeutic and developmental aspects of acute renal failure in children at the Mother-Child University Hospital Center Jeanne Ebori Foundation from 2021 to 2022
DOI:
https://doi.org/10.18203/2349-3291.ijcp20242726Keywords:
Renal failure, Creatinemia, GFR, Haemodialysis, LibrevilleAbstract
Background: Acute renal failure (ARF) is a major public health problem. Little is known about its prevalence in children. The aim of this study is to describe the epidemiological aspects of acute renal failure in children at the Mother-Child CHU Jeanne Ebori Foundation (CHUMEFJE) from 2021 to 2022.
Methods: This was a retrospective study conducted over 12 months at the CHUMEFJE. All children aged between one month and 18 years with ARF, defined as creatinine clearance <100 ml/min/1.73m2 or hourly diuresis <0.5 ml/kg for more than 6 hours, were included. Data analysis was performed using EPI info 7.2.2.
Results: Out of 3202 children, 251 had ARF, i.e. a prevalence of 7.8%. A total of 243 children were included. The mean age was 2.1±3.6 years. The 0-5 age group accounted for 85.6%. Clinical signs were dominated by AEG (88.5%), fever (85.6%) and dehydration (54.7%). ARF was functional (85.2%). The main causes were AEG (56.4%), malaria (26.3%) and urinary tract infection (5%). Eight (8) patients were on haemodialysis. Cure was noted in 63.8% of cases. Death was attributed mainly to the patient's past history. AEG was the main cause of AKI in the under-5s, and malaria in the 10-15 age group (p<0.001).
Conclusion: ARI is a global public health problem. Low socio-economic status and inadequate technical facilities complicate management.
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References
Tschumi S. Caccia J. Wagner S. Acute renal failure in children. Paediatrica 2020;31:30-5.
Akolly DAE. Tsevi YM. Djadou EK. Guedenon KM. Amekoudi ME. Tsolenyanu E, et al. Aetiological and evolutionary profile of renal failure in children in hospitals in Togo. Nephrology and Therapeutics. 2019;15(6):448-51.
De la Fuente V. Stucker F. Saudan P. Epidemiology of community-acquired acute renal failure. Rev Med Suisse. 2014;10:470-3.
Ciccia E. Devarajan P. Pediatric acute kidney injury: prevalence. impact and management challenges. Int J Nephrol Renovasc Dis. 2017;10:77-84.
5. Tondi Moussa ZM. Garba M. Abderraman Mahamat G. Renal failure in children aged 0-15 years: a multicentre study. Revue Scientifique du Tchad 2016:22-7.
Keita Y. Ka EF. Cisse MM. Sylla A. Acute renal failure in children: diagnostic. therapeutic. evolutionary and prognostic aspects of 50 cases from a paediatric unit in Dakar. Rev Cames Sante. 2015;3:55-60.
Halle MP. Lapsap CT. Barla E. Fouda H. Djantio H. Moudze KB et al. Epidemiology and outcomes of children with renal failure in the pediatric ward of a tertiary hospital in Cameroon. BMC Pediatrics. 2017;17(202):1-7.
Kéita Y. Ndongo AA. Ly F. Cisse N. Yamba NDM. Niang B. et al. Prevalence of Renal Failure in Children and the Need for Dialysis in Paediatric Nephrology in a Developing Country. Open J Nephrol. 2022;12:101-11.
Korula S. Balakrishnan S. Sundar S. Paul V. Balagopal A. Acute kidney injury-incidence. prognostic factors. and outcome of patients in an Intensive Care Unit in a tertiary center: A prospective observational study. Indian J Crit Care Med. 2016;20(6):332-6.
Urban and Municipal Development Fund. Urban diagnostic study of Libreville (Gabon). 2021. Available at: https://www.afdb.org/sites/default.
Wathi. Dakar: demographic situation. 2017. Available at: https://senegal2019.org/gouvernance.
Db-city. Ludhiana. 2021. Available at: https://fr.db-city.com/Inde--Penjab--District.
Bresolin N. Silva C. Halllal A. Toporovski J. Fernandes V. Góes J. et al. Prognosis for children with acute kidney injury in the intensive care unit. Pediatr Nephrol. 2009;24:537-44.
Moyen E. Bomelefa BV. Ekouya BG. Sinomono TE. Oko G. Mbolla E. et al. Acute renal failure in children at the University Hospital of Brazzaville. Open J Pediatr. 2019;9(3):253-72.
Olowu WA. Adefehinti O. Bisiriyu AL. Hospital-acquired acute kidney injury in critically ill children and adolescents. Saudi J Kidney Dis Transpl. 2012;23:68-77.
Batouche DD. Kerboua K. Prognosis of acute renal failure in children in intensive care unit: a pilot study. Curr Pediatr Res. 2016;20:193-8.
Rustagi RS. Arora K. Das RR. Pooni PA. Singh D. Incidence. risk. factors and outcome of acute kidney injury in critically ill children - a developing country perspective. Paediatrics and International Child Health. 2017;37(1):35-41.
Yadav SP. Shah GS. Mishra OP. Baral N. Renal data from Asia-Africa. Saudi J Kidney Dis Transpl. 2016;27(2):371-6.
Coulibaly PNA. Cisse L. Diarrassouba G. Egesi M. Tia WM. Ouattara GJ. et al. Renal and urinary diseases in children hospitalised in the paediatric department of Treichville University Hospital (Abidjan). Med Afr Noire. 2015;62:321-6.
Ocheke IE. Okolo SN. Bode-Thomas F. Agaba EI. Pattern of childhood renal diseases in Jos. Nigeria: a preliminary report. J Med Tropics. 2010;12:52-5.
Coulibaly G. Savadogo H. Bakoné BE. Karambiri A. Kouéta F. Hien KM. et al. Epidemiology of renal failure in children at the pediatric university hospital charles De-Gaulle of Ouagadougou (Burkina Faso). Open J Pediatr. 2016;6(1):141-8.
Okoronkwo NC. Chappjumbo AU. Onyire BN. Ekpemo SC. Ijeoma. SN. Pattern of childhood renal diseases in aba. South East Nigeria. Am J Pediatr. 2020;6(3):285-91.
Ali ETM. Rahman AH. Karrar ZA. Pattern and outcome of renal diseases in hospitalized children in Khartoum State. Sudan. Sudan J Paediatr. 2012;12(2):52-9.
Nebie YY. Aspects épidémiologiques. cliniques. paracliniques et étiologiques de l'insuffisance rénale chez l'enfant au Centre Hospitalier Universitaire Sourô Sanou de Bobo-dioulasso. Doctor of Medicine thesis. University of Ouagadougou; 2012. Available at: https://beep.ird.fr/collect/uouaga.
Kunuanunua TS. Nsibu CD. Gini-Ehungu JL. Mabiala B. Mfutu E. Situakibanza H et al. Acute renal failure in severe forms of malaria in living children in Kinshasa. Nephrolther. 2013;9:160-5.
Adekanmbi AF. Ogunlesi TA. Fetuga MB. Obadina OO. Adekoya OA. Pattern of renal diseases among hospitalised children in Sagamu. African J Sci 2015;1(1):1-4.
Cochran WJ. Gastroenteritis in children. MSD manual for health professionals. 2021. Avialable at: https://www.msdmanuals.com/fr/accueil.
Ndongo AA. Seck N. Thiam L. Sow NF. Faye AA. Basse I et al. Renal failure during childhood malaria at Dakar University Hospital. Health Sci Dis. 2022;23(5):57-60.
Balaka B. Douti K. Gnazingbe E. Bakonde B. Agbèrè AD. Kessie K. Etiologies and prognosis of renal failure in children at Lomé University Hospital. J Rech Sci Univ 2012;14:11-8.
Essola L. Mowangue PS. Minko J. Soami V. Sima Zué A. Ngomas J. Management of Acute Renal Failure in Severe Malaria in Children at the University Hospital of Libreville. A Study of 12 Cases. Health Sci Dis 2019;20(4):57-61.
Kaushik RL. Kaushik RM. Kakkar R. Shamar A. Chandra H. Plasmodium vivax malaria complicated by acute kidney injury: experience at a referral hospital in Uttarakhand. India. Tran R Soc Med Hyg 2013;107:188-94.
Junior MJA. Torres FR. Rodriges SAP. Araùjo DFM. Urinary tract infections in children and their renal repercussions. Revista Científica Multidisciplinar Núcleo do Conhecimento 2019;8(4):38-45.
Fouda Menye Ebada HD. Nguidjoe EM. Ajomo JC. Mahamat M. Nzana V. Halle MP et al. Clinical profile of acute renal injury associated with traditional medicines (ARAMT) in two general hospitals in Cameroon. Health Sci Dis. 2021;22(10):1-8.
Esezobor CI. Ladapo TA. Osinaike B. Lesi FEA. Paediatric acute kidney injury in a tertiary hospital in Nigeria: prevalence. causes and mortality rate. PloS one. 2012;7(12):51229.
Krishnamurthy S. Narayanan P. Prabha S. Mondal N. Mahadevan S. Biswal N. et al. Clinical profile of acute kidney injury in a pediatric intensive care unit from Southern India: a prospective observational study. Indian J Crit. 2013;17(4):207-13.
Bourquia A. Eke F. Anochie I. Harcourt P. ARI in countries with limited resources. In: Bourquia A. African guide to paediatric nephrology. Casablanca: Prestige diffusion. 2014;213-36.
Chelghoum S. Nadjmi M. Ferahta I. Haddoum F. Hamlaoui MT. Chabani S. et al. L'IRA chez l'enfant: expérience du CHU Hussein-Dey. Alger. Nephrol Ther. 2014;10(5):357.
Olowu WA. Niang A. Osafo C. Ashuntantang G. Arogundade F. Porter J. et al. Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review. Lancet Glob Health. 2015;4(4):242-50.
Oubella A. Acute renal failure in children at the Mohamed VI University Hospital in Marrakeck. Thèse de médecine. CADI AYYAD University. Marrakech. 2015;11:155.
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