Childhood brainstem lesions
DOI:
https://doi.org/10.18203/2349-3291.ijcp20242342Keywords:
Brainstem gliomas, MRI, Molecular pathology, Multidisciplinary approachAbstract
Brainstem gliomas are more common in the paediatric age group as compared to adults. They have variable clinical presentations, which can range from mild to severe. Radiographic appearance on MRI, anatomical location, and molecular pathology plays a key role in management and prognostication. A multidisciplinary approach based upon the extent and type of tumour is followed. In our study, we have reported 3 such cases who presented in different ways and were diagnosed as brainstem glioma. We have also discussed various modalities of investigation and management.
Metrics
References
Collins VP. Pathology of gliomas and developments in molecular testing. Clin Oncol. 2014;26:377-84.
Das KK, Mehrotra A, Nair AP. Pediatricglioblastoma: clinico-radiological profile and factors affecting the outcome. Childs Nerv Syst. 2012;28(12):2055-62.
Kebudi R, Cakir FB, Agaoglu FY. Paediatric diffuse intrinsic pontine glioma patients from a single centre. Childs Nerv Syst. 2013;29(4):583-8.
Kumar AJ, Leeds NE, Kumar VA, Fuller GN, Lang FF, Milas Z, et al. Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. J Comput Assist Tomogr. 2010;34(4):601-11.
Scott RM. Surgical outcome following resection of contrast-enhanced paediatric brainstem gliomas. Pediatr Neurosurg. 2004;40(2):99.
Zhang S, Wang X, Liu X, Ju Y, Hui X. Brainstem gangliogliomas: a retrospective series. J Neurosurg. 2013;118(4):884-8.
Alexiou GA, Tsiouris S, Kyritsis AP, Voulgaris S, Argyropoulou MI, Fotopoulos AD. Glioma recurrence versus radiation necrosis: accuracy of current imaging modalities. J Neurooncol. 2009;95(1):1-11.
Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012;124(3):439-47.
Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, et al. The genomic landscape of diffuse intrinsic pontine glioma and paediatric non-brainstem high-grade glioma. Nat Genet. 2014;46(5):444-50.
Taylor KR, Mackay A, Truffaux N, Butterfield YS, Morozova O, Philippe C, et al. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Nat Genet. 2014;46(5):457-61.
Horbinski C, Hamilton RL, Nikiforov Y, Pollack IF. Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytoma. Acta Neuropathol. 2010;119(5):641-9.
Jones DT, Gronych J, Lichter P, Witt O, Pfister SM. MAPK pathway activation in pilocytic astrocytoma. Cell Mol Life Sci. 2012;69(11):1799-811.
Jain R, Poisson L, Narang J, Scarpace L, Rosenblum ML, Rempel S, et al. Correlation of perfusion parameters with genes related to angiogenesis regulation in glioblastoma: a feasibility study. AJNR Am J Neuroradiol. 2012;33(7):1343-8.
Choi C, Ganji SK, De Berardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012;18(4):624-9.
Pirotte BJ, Lubansu A, Massager N, Wikler D, Goldman S, Levivier M. Results of positron emission tomography guidance and reassessment of the utility of and indications for stereotactic biopsy in children with infiltrative brainstem tumors. J Neurosurg. 2007;107(5):392-9.
Puttick S, Bell C, Dowson N, Rose S, Fay M. PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma. Drug Discov Today. 2015;20(3):306-17.
Halperin EC, Wehn SM, Scott JW. Selection of a management strategy for paediatric brainstem tumours. Med Pediatr Oncol 1989;17:116-25.
Packer RJ, Nicholson HS, Vezina LG, Johnson DL. Brainstem gliomas. Neurosurg Clin N Am 1992;3:863-79.
Downloads
Published
How to Cite
Issue
Section
