Correlation between the prothrombin time values obtained by point-of care prothrombin time meter and clinical laboratory in paediatric intensive care unit of a developing country

Najmi Usman; Muhammad Fareeduddin; Humaira Mustafa; Rabeea Tariq; Anwarul Haque; Rahim Ahmed; Usman Shakil

doi:10.18203/2349-3291.ijcp20242330

Authors

Najmi Usman Department of Pediatric Intensive Care, Dow University of Health Sciences Ojha Campus, Karachi, Pakistan
Muhammad Fareeduddin Department of Pediatric Intensive Care, Indus Hospital and Health Network, Karachi, Pakistan
Humaira Mustafa Department of Pediatric Intensive Care, Agha Khan University Hospital, Karachi, Pakistan
Rabeea Tariq Department of Pediatric Intensive Care, Indus Hospital and Health Network, Karachi, Pakistan
Anwarul Haque Department of Pediatric Intensive Care, Sindh Institute of Child Health and Neonatology, Karachi, Pakistan
Rahim Ahmed Department of Pediatric Intensive Care, Indus Hospital and Health Network, Karachi, Pakistan
Usman Shakil Department of Diagnostic, Bahria University Health Sciences Campus, Karachi, Pakistan

DOI:

https://doi.org/10.18203/2349-3291.ijcp20242330

Keywords:

Laboratory, PICU, Plasma, POC, PT

Abstract

Background: Monitoring of prothrombin time (PT) is essential for adequate management of children in pediatric intensive care unit (PICU) who require serial and repeated PT measurements. In contrast to laboratory testing, point-of-care (POC) PT meters have been configured especially for bedside that are cost effective with rapid turnaround time. Our study aimed to assess its feasibility for routine use in PICU by assessing the correlation between PT values obtained through the POC PT meter and those acquired from the laboratory.

Methods: A total of 200 children of either gender aged between 1 month to 12 years, admitted to PICU of Indus hospital Karachi Pakistan from February to August 2023 were analysed in this cross-sectional study. Venous blood samples were collected in PT bottles and transported to the pathology department within a time frame of 20-30 minutes for analysis. Concurrently, a drop of blood was obtained via finger prick and promptly assessed using the POC device-Coaguchek INRange system, (Roche diagnostics Ltd, USA). Pearson’s correlation was applied.

Results: 200 children (96 males, 104 females) having a mean age of 6.42±3.55 years. The mean PT values with POC meter and Laboratory were 2.588±1.299 and 2.574±1.304 respectively (p=0.100). Very strong correlation of PT between POC PT meter and laboratory evaluation was observed (r=0.996, p<0.001).

Conclusions: The strong correlation observed between POC PT meter and laboratory supports the use of these devices for timely coagulation monitoring, potentially improving patient outcomes in PICUs.

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