Platelet count and its indices as diagnostic markers of neonatal sepsis: a cross-sectional study


  • Sweety Goyal Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, India
  • Chandra M. Sharma Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, India
  • Ravish Kumar Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, India
  • Nitesh Mohan Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, India



Neonatal sepsis, Platelet count, MPV, Thrombocytopenia, PDW


Background: Neonatal sepsis is a critical condition posing a significant threat to newborns globally, particularly in developing countries. The non-specific symptoms and time-consuming traditional diagnostic methods highlight the need for rapid and reliable biomarkers. Recent studies suggest platelet count and indices such as mean platelet volume (MPV) and platelet distribution width (PDW) as potential indicators for early diagnosis of neonatal sepsis. This study aimed to assess the correlation between platelet count and its indices and neonatal sepsis.

Methods: A hospital-based cross- sectional study was conducted at NICU of tertiary care hospital involving 80 neonates with suspected sepsis. Platelet count, PDW, and MPV were measured and correlated with neonatal sepsis. Statistical analyses were performed using SPSS software, with a significance set at p<0.05.

Results: Of the 80 neonates studied, 22.5% exhibited thrombocytopenia. There was a noteworthy inverse relationship discovered between platelet count and sepsis, while MPV and PDW were higher. Gram-negative organisms were the most common cause of sepsis, out of which E. Coli (63.64%) was the most common.

Conclusions: The study confirmed a significant association between platelet count and indices with neonatal sepsis. Platelet count, MPV, and PDW can serve as effective, rapid diagnostic markers, potentially improving early detection and outcomes in neonatal sepsis.


Jatsho J, Nishizawa Y, Pelzom D, Sharma R. Clinical and bacteriological profile of neonatal sepsis: a prospective hospital-based study. Int J Pediatr. 2020;2020:1-9.

James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789-858.

Bangi VA, Devi SS. Neonatal sepsis: A risk approach. J Dr. NTR Uni Health Sci. 2014;3(4):254-8.

Guida JD, Kunig AM, Leef KH, McKenzie SE, Paul DA. Platelet count and sepsis in very low birth weight neonates: is there an organism specific response? Pediatrics. 2003;111(6 Pt 1):1411-5.

Guclu E, Durmaz Y, Karabay O. Main inflammatory parameters in acute appendicitis: are they predictable? Polish J Surg. 2010;82(5):278-82.

Bhat SA, Lone R, Mir MS. Platelet indices in neonatal sepsis: a review. J Pediatr Neonatal Individualized Med. 2017;6(2):e060237.

Patrick CH, Lazarchick J, James MO. Use of platelet indices in the differential diagnosis of neonatal thrombocytopenia. J Perinatol. 2012;32(7):514-9.

Nelson A, Kehl D. The role of mean platelet volume in the early diagnosis of acute appendicitis. Am J Emergency Med. 2011;29(9):1003-5.

Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflam. 2016;2019:9213074.

Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiologica. 2006;72(9):749-56.

Catal F, Tayman C, Tonbul AL, Akça HA, Kara SE, Tatli MM, et al. Mean platelet volume (MPV) may simply predict the severity of sepsis in preterm infants. Clin Lab. 2014;60(7):1193-200.

Arif SH. Thrombocytopenia and bacterial sepsis in neonates. Indian J Hematol Blood Transf. 2012;28(3):147-51.

Choudhary RR, Makwana M, Mourya HK, Dabi J, Gulati K. Evaluation of platelet and its indices as a marker of neonatal sepsis: a prospective case control study. Int J Contemp Pediatr. 2018;5(5):1898-903.

Aydemir C, Aydemir H, Kokturk F, Kulah C, Mungan AG. The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis. BMC Pediatrics. 2018;18:1-2.

Wang J, Wang Z, Zhang M, Lou Z, Deng J, Li Q. Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis. Medicine. 2020;99(32):e21649.

Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, Park KS, et al. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PloS One. 2015;10(3):e0119437.

Meena IL. Correlation between neonatal sepsis with serum CRP and platelet indices (platelets count, MPV and PDW). Int J Adv Med. 2017;1(6):8- 10.

Mittal A, Arya S, Charan LS, Saluja S, Chellani H. Evaluation of platelet indices as additional diagnostic tool for neonatal sepsis. Astrocyte. 2018;4(4):205-9.

Salama K, Gad A, El Tatawy S. Sepsis profile and outcome of preterm neonates admitted to neonatal intensive care unit of Cairo University Hospital. Egypt Pediatr Assoc Gazette. 2021;69:1-9.

Turhan EE, Gürsoy T, Ovalı F. Factors which affect mortality in neonatal sepsis. Turk Arch Pediatr. 2015;50(3):170.

Kumar DV, Mohan J, Rakesh PS, Prasad J, Joseph L. Bacteriological profile of neonatal sepsis in a secondary care hospital in rural Tamil Nadu, Southern India. J Family Med Primary Care. 2017;6(4):735-8.






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