A comparative study of cord blood lipid profile in term, pre term and small for gestational age - appropriate for gestational age neonates


  • Ramanathan Department of Paediatrics, Government Cuddalore Medical College, Chidambaram, Tamil Nadu, India
  • Thivyabharathi Raguraman Department of Paediatrics, Government Cuddalore Medical College, Chidambaram, Tamil Nadu, India




Cord blood lipid profile, Preterm, Term, AGA, Small for gestational age


Background: Cord blood lipid profile in neonates helps to screen for neonatal dyslipidaemia which is associated with long term morbidity mainly cardiovascular disease.

Methods: The present study is a observational study done in government medical college, Chidambaram for a period of 2 years from October-2020 till September-2022 with 222 term and pre-term small or appropriate for gestational age (AGA) neonates using cord blood lipid profile.

Results: In the present study of above mentioned 222 neonates, preterm accounts for 30.1% and term neonates accounts for 69.9%. AGA was 63.1% and SGA was 36.9%. Term AGA was 38.2%, term SGA 31.5%, preterm AGA was 24%, preterm SGA was 5.4%. 

Conclusions: Preterm AGA had higher cord lipid profile values compared to the term AGA neonates. Preterm SGA neonates had lower cord lipid profile of HDL, and LDL as compared to preterm AGA neonates. SGA neonates had higher total cholesterol, triglycerides and VLDL compared to AGA neonates. SGA neonates had lower LDL and HDL as compared to AGA neonates.


Kent L, Thomburg. Fetal Origins of Cardiovascular Disease. Am Academy Pediatr. 2004;5(12):527-34.

Verkauskiene R, Czernichow P, Claire LM. Long-term metabolic consequences of being born small for gestational age. Expert Rev Endocrinol Metabol. 2006;1(1):439-47.

Jones J N, Taylor Gercel, Taylor Doughlas D. Altered cord serum lipid levels associated with small for gestational age infants. J Am College Obstetr Gynaecol. 1999;93:527-31.

Kelishadi R, Badiee Z, Adeli K. Cord blood lipid profile and associated factors: bascline data of a birth cohort study. Paediatric Perinatal Epidemiol. 2007;21:518-24.

Pardo IMCG, Geloneze B, Tambascia MA, Barros Filho AA. Atherogenic lipid profile of Brazilian near term newborns. Braz J Med Biolog Res. 2005;38(5):755-60.

Singh J, Purohit M, Singh P, Thappa DM. Cord Blood Cholesterol in Term and Preteterm Newborns. Indian Pediatr. 1994(31):1278-80.

Daniel ML, Walter JM. Factors affecting the lipid and Apolipoprotein levels of cord sera. Pediatr Res. 1983;17:83-91.

Averna MR, Barbagallo CM, Dipaola G, Labisi M, Pinna G, Marino G, et al. Total cholesterol IDL-Cholesterol and lipoprotein B in umbilical cord blood: cross sectional study. Minerva-Pediatr. 1992;44:395-9.

Hossain MA, Islam MN, Shahidullah M, Akhter H. Serum triglyceride level in IUGR babies and its comparison with preterm AGA and term normal babies. Mymensingh Med J. 2006;15(2):180-82.

Oba J, Sirlei Donega, Raul C, Maranhao Concentration of serum lipids and Apolipoprotein B in Newborn. Arquivos Brasileiros Cardiol. 2006;31(86):6.

Leon DA, Lithell HO, Vagero D, Koupilova I, Mohsen R, Berglund L, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15000 Swedish men and women born 1915-29. Br Med J. 1998;317(7153):241-5.

Rich-Edwards JW, Stampfer MJ, Manson JE, Rosner B, Hankinson SE, Colditz GA, et al. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. Br Med J. 1997;315(3):96-400.

Kalra A, Kalra K, Agarwal MC, Prasad R, Pant MC Bhatia R, et al. Serum lipid profile in term and preterm infants in early neonatal period Indian Pediatr. 1988;2:977-81.

Mishra PK, Tiwari DK, Sharma B, Kaul R. Free fatty acids and Triglycerides in normoglycemic low birth weight newborns in Carly neonatal period. Indian J Pediatr. 1984;51(1):637-41.

Haridas N, Acharya PT. Serum Lipid Status in neonates. Indian Pediatr. 1984;21(4):327-34.

Mathur PP, Prasad R, Jain SK, Pandey DH, Singh SP. Cord blood Cholesterol in term and preterm newborns. Indian Pediatr 1986;23(2):103-6.






Original Research Articles