Assessment of growth among children with type 1 diabetes mellitus

Authors

  • Mallanagouda Kuberagouda Pavadigoudra Department of Pediatrics, MMC and RI, Mysore, Karnataka, India
  • Sujata B. Sajjanar Department of Pediatrics, IGICH, Bangalore, Karnataka, India
  • Uday K. Department of Pediatrics, KIMS, Koppal, Karnataka, India
  • Ushakiran C. B. Department of Pediatrics, MMC and RI, Mysore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20242014

Keywords:

T1DM, HbA1C, Height

Abstract

Background: As insulin is important regulator of growth hormone related factors, especially insulin like growth factors (IGF-1) and insulin like growth factors binding proteins (IGFBP-3), disorders of insulin production can result in poor growth. Studies suggest that growth abnormalities are common in subjects with poor metabolic control and longer disease duration. Growth parameters are important indicators of a child overall health and they are influenced by factors like blood glucose control in diabetic children.

Methods: After obtaining institutional ethical committee clearance and informed consent from parents/subjects, a prospective observational study was conducted from January 2018 to June 2019. Anthropometry of each participant (height, weight, BMI) measured and 4 ml of venous blood was collected for HbA1C levels. Results were compared with age specific standards. Anthropometry and blood investigations performed once in 3 months for 1 year.

Results: Out of 30 cases, 53.3% (n=16) were males and 46.7% (n=14) were females with M:F ratio of was 1:1.04. Among those with poor HbA1C control 73.69% (n=14) had short stature at the entry of the study and the results was statistically significant (p=0.043). Among those with poor HbA1C control, 72.73% (n=08) had short stature at the one year follow up and the results was statistically significant (p=0.017). Which suggests that linear growth in children with type 1 diabetes is highly related to glycemic control.

Conclusions: Growth was compromised in diabetic children. Children diagnosed at younger age need monitoring of good glycemic control and drug compliance to optimize the growth.

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References

Chiarelli F, Giannini C, Mohn A. Growth, growth factors and diabetes. Eur J Endocrinol. 2004;151(3):U109-17.

Holl RW, Grabert M, Heinze E, Sorgo W, Debatin KM. Age at onset and longterm metabolic control affect height in type-1 diabetes mellitus. Eur J Pediatr. 1998;157(12):972-7.

Timóteo C, Castanhinha S, Constant C, Robalo B, Pereira C, Sampaio L. Growth and puberty in type 1 diabetes mellitus - experience from a pediatric endocrinology unit. Acta Med Port. 2012;25(4):213-83.

Salerno M, Argenziano A, Di Maio S, Gasparini N, Formicola S, De Filippo G, et al. Pubertal growth, sexual maturation, and final height in children with IDDM. Effects of age at onset and metabolic control. Diabetes Care. 1997;20(5):721-4.

Khadilkar VV, Parthasarathy LS, Mallade BB, Khadilkar AV, Chiplonkar SA, Borade AB. Growth status of children and adolescents with type 1 diabetes mellitus. Indian J Endocrinol Metab. 2013;17(6):1057-60.

Atkinson MA, Eisenbarth GS, Michels AW. The natural history of type 1 diabetes Type 1 diabetes. Lancet. 2014;73(1):69-78.

Atkinson MA, Eisenbarth GS, Michels AW: Type 1 diabetes. Lancet. 2014;383(9911):69-78.

Townsend T. A decade of diabetes research and development. International Journal of Diabetes and Metabolism 2000;8(3):88-92.

Amos AF, McCarty DJ, Zmmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabetic Med. 1997;14(5):S1-85.

Ali K, Harnden A, Edge JA: Type 1 diabetes in children, BMJ 342:d294, 2011 Dabelea D: The accelerating epidemic of childhood diabetes, Lancet. 2009;373(9680):1999-2000.

Writing Group for the SEARCH for Diabetes in Youth Study Group, Dana D, Ronny AB, Ralph BD Jr, Giuseppina I, Judith MJ, et al. Incidence of diabetes in youth in the United States, JAMA. 2007;297(24):2716-24.

International Diabetes Federation. IDF Diabetes Atlas, 8th edn. Brussels, Belgium: International Diabetes Federation, 2017. Available at: http://www.diabetesatlas.org. Accessed on 17 February 2024.

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Published

2024-07-26

How to Cite

Pavadigoudra, M. K., Sajjanar, S. B., K., U., & B., U. C. (2024). Assessment of growth among children with type 1 diabetes mellitus. International Journal of Contemporary Pediatrics, 11(8), 1057–1060. https://doi.org/10.18203/2349-3291.ijcp20242014

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Original Research Articles