Novel therapeutic approaches for steroid-resistant nephrotic syndrome in paediatric patients: a comprehensive review


  • Rajan Kumar Department of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India
  • Santosh Kumar Department of Pediatrics, Maulana Azad Medical College, Delhi, India
  • Deepak Kumar Department of PMR, All India Institute of Medical Sciences, Deoghar, Jharkhand, India
  • Ehtesham Ansari Department of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India



SRNS, Extracorporeal therapy, Galactose, ACTH


Steroid-resistant nephrotic syndrome poses a significant therapeutic challenge in paediatric nephrology. Previously exact cause of steroid-resistant nephrotic syndrome was mostly unknown. Recently, advancements in diagnostic intervention, they are found to be a heterogeneous entity having an immune basis and genetic aetiology. With a better understanding of the pathogenesis of SRNS, leading to the development of novel therapeutic strategies. Novel therapeutic options include extracorporeal therapy, monoclonal antibodies, stem cell therapy, ACTH and galactose. The aim of this study was to provide an overview of emerging therapies for SRNS in paediatric populations.


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