Disseminated juvenile xanthogranuloma secondary to chemotherapeutic treatment of acute lymphoblastic leukemia

Authors

  • Alondra Saray Polanco Llanes Department of Dermatology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
  • Carla Itzel Figueroa Basurto Department of Dermatology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
  • Clariza Cecilia Infante Fernández Department of Dermatology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico
  • Ana María Medina Torres Department of Dermatology, Medica Scop Private Hospital, Mexico City, Mexico
  • María Elisa Vega Memije Department of Dermatology, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico

DOI:

https://doi.org/10.18203/2349-3291.ijcp20241372

Keywords:

Juvenile xanthogranuloma, Acute lymphoblastic leukemia, Non-langerhans cells

Abstract

Juvenile xanthogranuloma is a benign, reactive, self-limiting disorder within the non-Langerhans cell histiocytosis group. It primarily affects infants and preschoolers, and occasionally in adults. Some cases report concurrent non-LCH and leukemia, with bone marrow being the second common pathology. We present a case of JXG with acute lymphoblastic leukemia in a 17-year-old male. Emphasizing the importance of considering the possibility of apparently disparate disorders in a patient, especially with unusual clinical findings.

 

References

Hernández-San MJ, Vargas-Mora P, Aranibar L. Xantogranuloma juvenil: una entidad con amplio espectro clínico. Actas Dermosifiliogr. 2020;111(9): 725-33.

Ayechu Díaz A, Navarro González D, Virto Ruiz MT. Xantogranuloma juvenil gigante. An Pediatr. 2012; 76(5):300-1.

Serra M, Villareal M, Hernandez M, Salduna M, Valente E, Kurpis M, et al. Xantogranuloma juvenil y leucemia linfática aguda. Dermatol Pediatr Latinoam. 2010;8(3):73-7.

Perez-Becker R, Szczepanowski M, Leuschner I, Janka G, Gokel M, Imschweiler T, et al. An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011; 56(5):859-62.

Chiou CC, Wang PN, Yang LC, Kuo TT, Hong HS. Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: a case report and review the association of haematologic malignancies. J Eur Acad Dermatol Venereol. 2007;21(4):532-5.

Pawińska-Wa̧sikowska K, Cwiklinska M, Wyrobek E, Balwierz W, Bukowska-Strakova K, Dluzniewska A, et al. Disseminated Juvenile Xanthogranuloma and Hemophagocytic Lymphohistiocytosis Developed During Treatment of Acute Lymphoblastic Leukemia: Case Report. Front Oncol. 2020;3:10.

Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa M, et al. Análisis genómico del origen clonal de la histiocitosis de células de Langerhans tras leucemia linfoblástica aguda. H J Hematol. 2016;175: 161-75.

Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, et.al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010;16(11):1919-23.

Dacic S, Trusky C, Bakker A, Finkelstein SD, Yousem SA. Genotypic analysis of pulmonary Langerhans cell histiocytosis. Hum Pathol. 2003; 34(12):1345-9.

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012;481(7380):157-63.

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Published

2024-05-27

Issue

Section

Case Reports