VDPV and polio end game strategy: the final frontier


  • Dewesh Kumar Department of Community and Family Medicine, AIIMS, Jodhpur-342005, Rajasthan, India
  • Neelesh Kapoor NPSP-WHO, SRTL, Lucknow, UP, India
  • Pankaja Ravi Raghav Department of Community and Family Medicine, AIIMS, Jodhpur-342005, Rajasthan, India
  • Mahendra Singh Gehlot Department of Community and Family Medicine, AIIMS, Jodhpur-342005, Rajasthan, India


Vaccine derived polio virus, Oral polio vaccine, Eradication


Polio eradication mission was impossible without the continual use of oral polio vaccine and it has set forth examples of its success all over the world. But the dynamics of OPV and low immunization coverage in some parts of world due to varied reasons is still a matter of concern due to the threat of Vaccine Derived Polio Virus (VDPV) and its circulation. The near eradication of poliomyelitis in whole world has intrigued the experts to control the VDPV and know more about their mutations and rising variations. Although their number are considerably less but they cannot be ignored and so  there is a dire need to strategically implement the polio end game plan and rapid containment of newly found virus in any part of the world.


Resolution WHA. 41.28. Polio eradication by the year 2000. In: Handbook of Resolutions and Decisions of the World Health Assembly and the Executive Board. 3rd ed. (1985-1992). Geneva Switzerland: WHO; 1993: 1-192.

Ghendon Y, Robertson SE. Interrupting the transmission of wild polioviruses with vaccine: immunological considerations. Bull WHO. 1994;72:873-83.

Agol VI. Molecular mechanisms of poliovirus variation and evolution. Curr Top Microbiol Immunol. 2006;299:211-59.

Agol VI. Vaccine-derived polioviruses. Biologicals. 2006;34:103-8.

Ehrenfeld E, Glass RI, Agol VI, Chumakov K, Dowdle W, John TJ, et al. Polio immunization: moving forward. Lancet. 2008;371:1385-7.

Kew OM, Sutter RW, de Gourville EM, Dowdle WR, Pallansch WA. Vaccine-derived polioviruses and the endgame strategy for global polio eradication. Annu Rev Microbiol. 2005;59:587-635.

CDC. Update on vaccine-derived polioviruses - worldwide, July 2009 - June 2011. Morb Mort Weekly Rep. 2011;60:846-50.

Polio Eradication. Vaccine derived polio virus (VDPV), 2014. Available at: http://www.polioeradication.org/Polioandprevention/Thevirus/Vaccinederivedpolioviruses.aspx. Accessed 3 April 2014.

Tebbens RJ, Pallansch MA, Kew OM, Carceres VM, Jafari H, Cochi SL, et al. Risks of paralytic disease due to wild or vaccine-derived poliovirus after eradication. Risk Anal. 2006;26:1471-505.

John TJ, Vashishtha VM. Eradication of vaccine viruses: why, when and how? Indian J Med Res. 2009;130:491-4.

John TJ. Polio eradication in India: what is the future? Indian Pediatr. 2003;40:455-62.

Polio Eradication. Polio eradication and end game strategic plan 2013-2018, 2014. Available at: http://www.polioeradication.org/Portals/0/Document/Resources/StrategyWork/PEESP_CH0_EN_US.pdf. Accessed 3 April 2014.