The study of clinical profile of severe dengue in children
DOI:
https://doi.org/10.18203/2349-3291.ijcp20240730Keywords:
Severe dengue, Warning signs, ShockAbstract
Background: Dengue fever is one of the most important vectors borne viral diseases, causing the significant burden due to high admissions and mortality in southern parts of India. Early detection and early intervention of sickness can reduce this burden for which we should know the clinical features and other parameter in dengue so that mortality rate can be reduced.
Methods: It was a retrospective single center study which included patients admitted to department of pediatrics from a period of October 2022 to November 2023. A total of 30 cases of severe dengue admitted in a span of 6 months. A detailed clinical and laboratory data was recorded in a questionnaire format which was analyzed using statistical tool.
Results: Among 30 cases of severe dengue the most common clinical feature was shock (53%), hepatitis (36%), clinical fluid accumulation (33%), mucosal bleeding (26%) and ARDS (165). Severe dengue was frequently found in the range of white cell count 1000-4000/ul and platelet count 12000-50000/ul.
Conclusions: The key to the management of severe dengue illness lies in the in-depth knowledge of clinical manifestation among children. Thus, it is important to be aware of warning signs and varied presentations of severe dengue so that there will be accurate management of in resource limited setups.
Metrics
References
Tantawichien T. Dengue fever and dengue haemorrhagic fever in adolescents and adults. Paediatr Int Child Heal. 2012;32(1):22-7.
Tanner L, Schreiber M, Low JG, Ong A, Tolfvenstam T, Lai YL, et al. Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness. PLoS Negl Trop Dis. 2008;2(3):e196.
Normile D. Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts. Science (New York, NY). 2013;342(6157):415.
Manock SR, Jacobsen KH, De Bravo NB, Russel KL, Negrete M, Olson JG, et al. Etiology of acute undifferentiated febrile illness in the Amazon basin of Ecuador. Am J Trop Med Hyg. 2009;81(1):146-51.
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;8(12):S7-16.
Huy R, Buchy P, Conan A, Ong S, Ali R, Duong V, et al. National dengue surveillance in Cambodia 1980-2008: epidemiological and virological and the impct of vector control. Bull World Health Organization. 2010;88(9):650-7.
Sam SS, Omar SF, Teoh BT, Abd-Jamil J, Abu Bakar S. Review of dengue hemorrhagic fever fatal cases seen among adults. PLoS Negl Trop Dis. 2010;88(9):650-7.
WHO. World Health Organization: a global brief on vector born disease. Geneva: World Health Organization. 2010. Available at: https://www.who.int/news-room/fact-sheets/detail/vector-borne-diseases. Accessed on 15 January 2024.
Ledika MA, Setiabudi D, Dhamayanti M. Association between clinical profiles and severe dengue infection in children in developing country. Am J Epidemiol Infect Dis. 2015;3(3):45-9.
Ravishankar K, Vinoth PN, Venkataramanan P. Biochemical and radiological markers as a predictor of dengue severity in children admitted to tertiary care hospital. Int J Contemp Pediatr. 2015;21-6.
Sahana KS, Sujatha R. Clinical profile of dengue among children according to revised WHO classification: analysis of 2012 outbreak from southern India. Indian. J. Pediatr. 2014;104.
Jagadish KK, Jain P, Manjunath VG, Umesh L. Hepatic involvement in dengue fever in children. Iran J. Pediatr. 2012;22(2):231-6.
Srinivasa S, Tanveer N, Chaithanya CN. Clinical profile and ultrasonographic findings in children with dengue fever. Curr Pediatr Res. 2014;18(2):87-90.
Harris E, Videa E, Perez L, Sandoval E, Tellez Y, Pérez ML, et al. Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg. 2000;63(1-2):5-11.
Setiati TE, Mairuhu AT, Koraka P, Supriatna M, Mac Gillavry MR, Brandjes DPM, et al. Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. BMC Infect Dis. 2007;7:22.
Murgue B, Deparis X, Chungue E, Cassar O, Roche C. Dengue: an evaluation of dengue severity in French Polynesia based on an analysis of 403 laboratory-confirmed cases. Trop Med Int Heal. 1999;4(11):765-73.
Phuong CX, Nhan NT, Kneen R, Thuy PT, Van Thien C. Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? Am J Trop Med Hyg. 2004;70:172-9.
Downloads
Published
How to Cite
Issue
Section
