Brucella anthropi infection in a 5-week-old infant


  • Prafful Gupta Department of Paediatrics, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India
  • Ruchi Rai Department of Neonatology, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India
  • D. K. Singh Department of Paediatrics, Post Graduate Institute of Child Health, Noida, Uttar Pradesh, India



Brucella anthropi, Blood culture, Unpasteurized breast milk


Congenital brucellosis in infants is well described but occurs rarely and very few cases have been reported till now. Acquired brucellosis in young infants has rarely been reported. A 5-week-old infant weighing 3340 gm, presented to the emergency with complaints of fever, abdominal distension, lethargy, and decreased feeding for five days. A clinical diagnosis of septicemia was made. Laboratory parameters were suggestive of septicemia. There was a history of ingestion of unpasteurized buffalo’s milk. Empirical antibiotics started after withdrawing the blood culture. Blood culture came positive for Brucella anthropi. Ultrasonography of the abdomen showed a small abscess in the left iliac fossa measuring 44×38 mm. The antibiotics were changed to piperacillin-tazobactam and amikacin as per the blood culture and sensitivity report. Supportive care was given, and the baby gradually improved. The child was discharged on oral rifampicin and trimethoprim-sulfamethoxazole for 4 weeks and is being followed up and is doing well. Young infants may acquire Brucella infection from breastmilk or ingesting unpasteurized animal milk. Prompt diagnosis and treatment is the key to management. Exclusive breastfeeding is the best way to prevent not only animal milk-acquired Brucella but most other types of infection.


Bukhari EE. Pediatric brucellosis: An update review for the new millennium. Saudi Med J. 2018;39(4):336-41.

Palanduz A, Palanduz Ş, Güler K, Güler N. Brucellosis in a mother and her young infant: Probable transmission by breast milk. Int J Infect Dis. 2000;4(1):55-6.

Zhao M, Huang F, Zhang A, Zhang B, Zeng L, Xu J, et al. Congenital brucellosis in a Chinese preterm neonate: A case report. J Int Med Res. 2019;47(5):2296-301.

Bhatnagar A, Khera D, Singh K, Sharma A. Acquired Brucella bacteraemia in a young infant. BMJ Case Rep. 2017;2017.

Alnemri ARM, Hadid A, Hussain SA, Somily AM, Sobaih BH, Alrabiaah A, et al. Neonatal brucellosis: A case report. J Infect Dev Ctries. 2017;11(2):199-202.

Lama M, Chanakya PP, Khamari B, Peketi ASK, Kumar P, Muddu GK, et al. Genomic analysis of a multidrug-resistant Brucella anthropi strain isolated from a 4-day-old neonatal sepsis patient. J Global Antimicrob Resist. 2021;26:227-9.

Al-Kharfy TM. Neonatal brucellosis and blood transfusion: case report and review of the literature. Ann Trop Paediatr. 2001;21(4):349-52.

Yagupsky P, Morata P, Colmenero JD. Laboratory Diagnosis of Human Brucellosis. Clin Microbiol Rev. 2019;33(1):e00073-19.

Roushan MR, Mohraz M, Janmohammadi N, Hajiahmadi M. Efficacy of cotrimoxazole and rifampcin for 6 or 8 weeks of therapy in childhood brucellosis. Pediatr Infect Dis J. 2006;25(6):544-5.

Al-Tawfiq JA, Memish ZA. Antibiotic susceptibility and treatment of brucellosis. Recent Pat Anti Infect Drug Discov. 2013;8(1):51-4.






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