Clinical outcome of babies born through meconium stained liqour
DOI:
https://doi.org/10.18203/2349-3291.ijcp20233241Keywords:
Mechanical ventilation, Meconium, Respiratory distressAbstract
Background: Meconium aspiration syndrome (MAS) is as a result of aspiration of meconium-stained amniotic fluid antepartum or postpartum in term or near-term infants resulting in respiratory morbidity of varying severity. The present study was conducted to assess the clinical outcome of babies born through meconium stained liquor.
Methods: This is a prospective observational study of babies born through meconium stained liquor at ESIC Medical College and Post Graduate Institute of Medical Science and Research over a period of 18 months from March 2021 to August 2022.
Results: Majority of the babies were born through thin MSL. The highest incidence of MSL is seen in term babies. Normal vaginal delivery was the predominant mode of delivery. Thick MSL babies had low APGAR score at 1min .Majority of the thick MSL group had moderate to severe respiratory distress. Thick MSL babies required invasive mechanical ventilation compared to thin MSL group. Thick MSL study group had moderate to severe meconium aspiration syndrome compared to thin MSL study group. Perinatal depression was the most commonly associated complication in this study. Sepsis and PPHN were the complications that lead to mortality among the study group. Higher morbidity was seen in thick MSL group. The overall mortality was 1.6% and morbidity 55.2%.
Conclusions: Thick meconium stained amniotic fluid is associated with increased risk perinatal depression, persistent pulmonary hypertension, sepsis, severe meconium aspiration syndrome and mortality.
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References
Antonowiez I, Schwachman H. Meconium in health and disease. Adv Paediatr. 1979;26(1):275-310.
Fanaroff AA. Meconium aspiration syndrome: historical aspects. J Perinatol. 2008;28(Suppl 3):S3-7.
Cleary GM, Wiswell TE. Meconium-stained amniotic fluid and the meconium aspiration syndrome: an update. Pediatr Clin North Am. 1998;45(3):511-29.
Cloherty JP, Eichenwald EC, Stark AR. Meconium Aspiration. Manual of Neonatal Care. 8th Ed. New Delhi: Lippincott Williams & Wilkins, a Wolters Kluwar business; 2019:461.
Bhutani VK. Developing a systems approach to prevent meconium aspiration syndrome: lessons learned from multinational studies. J Perinatol. 2008;28(Suppl 3):S30-5.
Poggi SH, Ghidini A. Pathophysiology of meconium passage into the amniotic fluid. Early Hum Dev. 2009;85(10):607-10.
Sankhyan N, Sharma VM. Predictors of meconium stained amniotic fluid: a possible strategy to reduce neonatal morbidity and mortality. J Obstet Gynecol India. 2006;56(6):514-7.
Ross MG. Meconium aspiration syndrome. J Med. 2005;350:946-8.
Louis D, Sundaram V, Mukhopadhyay K, Dutta S, Kumar P. Predictors of mortality in neonates with meconium aspiration syndrome. Indian pediatrics. 2014;51:637-40.
Shilpasri YM, Madhurya B. Clinical study of babies born through meconium stained amniotic fluid. Int J Contemp Pediatr. 2019;6:491-6.
Akhila S, Koppad AM, Aundhakar CD. Study of neonatal outcome in meconium stained amniotic fluid. Inter J Med Health Res. 2018;4(3):134-38.
Satendra Singh Rajput et al., Sch. J. App. Med. Sci., Sep 2016; 4(9E):3548-3552
Raju V. Immediate clinical outcome of newborns with meconium stained amniotic fluid in an urban referral centre (Doctoral dissertation, Madras Medical College, Chennai). Int J Contemp Pediatr. 2018;5(5):1824-7.
Manivannan V, Jegan Murugan R, Devandiran RS. A study on clinical profile of meconium aspiration syndrome in relation to gestational age and birth weight and their immediate outcome Int J Contemp Pediatr. 2019;6(6):2346-51.
Dhannaram V, Kotapuri S, Chitgupikar S. Study of early neonatal outcomes in babies delivered through meconium-stained amniotic fluid in a rural teaching hospital. Int J Contemp Pediatr. 2021;8(4):642-6.
Priti Singh, Surendra Nath Soren. A study of perinatal outcome in meconium stained amniotic fluid. MedPulse-Inter Medi J. 2017;4(1):06-13.
Patil VB, Sonwane VB, Kumbhojkar S, Sarawade S. A prospective clinical study of babies born with meconium stained liquor delivered by caesarean and pervaginal delivery. Int J Health Sci Res. 2017;7(8):44-53.
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